Description

Pc Spdp-Nhs Carbonate Ester CAS NO 2279944-61-3 is a specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation applications. Its core value lies in its dual reactive groups, enabling the controlled and sequential coupling of biomolecules such as proteins, peptides, and oligonucleotides under mild conditions. This compound is essential for researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced materials science who require precise and stable linkages.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Protein-Protein/Peptide Conjugation: Creating stable complexes for structural studies, immunoassays, or therapeutic proteins.
• Surface Immobilization of Biomolecules: Functionalizing biosensor chips, microarray slides, or nanoparticles with active proteins or DNA.
• Polymer Modification: Introducing bioactive ligands onto polymeric carriers for targeted drug delivery systems.
• Enzyme Labeling: Attaching reporter molecules (e.g., fluorophores, enzymes) to proteins for diagnostic applications.
• Stable Crosslinking in Material Science: Used in the development of hydrogels or biomimetic materials with controlled mechanical properties.

Basic Information

Product Name	Pc Spdp-Nhs Carbonate Ester
CAS No.	2279944-61-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	SPDP-PC-NHS Carbonate; N-Hydroxysuccinimide ester of SPDP-PC carbonate; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinimidyl(polyethylene glycol)-2000]-3-(2-pyridyldithio)propionate; DSPE-PEG(2000)-SPDP-NHS; Heterobifunctional PEG-SPDP-NHS crosslinker; Pyridyldithiopropionyl-PEG-NHS ester; NHS-PEG-SPDP
EINECS	Contact for details

Quality Control

Our Pc Spdp-Nhs Carbonate Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support development under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize condensation. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, Chloroform
Functional Group Substitution	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.