Description

Propargyl-Peg12-Amine is a heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a primary amine, connected by a 12-unit PEG spacer. This compound is a critical building block in bioconjugation and click chemistry, enabling the site-specific attachment of biomolecules, polymers, and small molecules under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, diagnostics, and advanced materials science who require precise and stable cross-linking strategies.

Application

• Bioconjugation Reagent: For the site-specific labeling of peptides, proteins, and antibodies via amine-reactive chemistry (NHS ester activation) combined with copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• PEGylation Linker: Used to create PEGylated therapeutics to improve pharmacokinetic properties such as solubility, stability, and circulation half-life.
• Polymer and Dendrimer Synthesis: Serves as a versatile monomer or cross-linker for constructing functionalized polymers, hydrogels, and dendritic structures.
• Diagnostic Probe Development: Facilitates the creation of fluorescent, radioactive, or other tagged probes for imaging and diagnostic assays.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and biosensor surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• Drug Delivery Systems: A key component in the design of targeted drug delivery carriers, such as antibody-drug conjugates (ADCs) and liposomal formulations.
• Materials Science: Used to introduce hydrophilic PEG chains and reactive handles into advanced materials for biomedical applications.
• Click Chemistry Tool: A fundamental reagent for modular synthesis in combinatorial chemistry and library development.

Basic Information

Product Name	Propargyl-Peg12-Amine
CAS No.	2264091-73-6
Molecular Formula	C29H57NO13
Molecular Weight	627.8 g/mol
Synonyms	Propargyl-PEG12-amine; Propargyl-PEG12-NH2; 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxa-38-azaheptatetracont-37-yn-1-amine; 1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxa-39-azanonatriacont-38-yne; Propargyl-O-(CH2CH2O)12-CH2CH2NH2; Alkyne-PEG12-amine; Propargyl PEGylated amine (n=12); Propargyl-PEG12-alkylamine
EINECS	Contact for details

Quality Control

Our Propargyl-Peg12-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to relevant industry standards for research and pharmaceutical-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.