Description

H2N-PEG27-CH2CH2NH2 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group at one terminus and a secondary amine group at the other, linked by a 27-unit PEG spacer. This unique bifunctional structure is critical for creating stable, hydrophilic, and biocompatible crosslinks and conjugates in advanced material science and biopharmaceutical applications. It is essential for researchers and manufacturers in the fields of bioconjugation, hydrogel formulation, and nanomaterial surface functionalization who require precise and reliable PEG-based linkers.

Application

• Bioconjugation and Protein Modification: Used to crosslink biomolecules, such as antibodies, peptides, or enzymes, to other entities (e.g., drugs, surfaces, or fluorescent dyes) while enhancing solubility and stability.
• Hydrogel and Biomaterial Synthesis: Serves as a versatile crosslinking agent for creating PEG-based hydrogels with tunable mechanical properties for tissue engineering and drug delivery scaffolds.
• Nanoparticle and Liposome Functionalization: Employed to modify the surface of nanoparticles or liposomes with amine-reactive groups, improving biocompatibility, circulation time, and targeted delivery capabilities.
• Diagnostic Reagent Development: Integral in the fabrication of diagnostic assays and biosensors, where it provides a stable, non-fouling spacer between the capture molecule and the solid support.
• Polymer Chemistry and Dendrimer Synthesis: Acts as a building block or linker in the synthesis of complex polymeric architectures and dendrimers for specialized material properties.
• Surface Coating and Immobilization: Applied to create hydrophilic, non-adhesive coatings on medical devices or sensor surfaces to prevent non-specific binding.

Basic Information

Product Name	H2N-PEG27-CH2CH2NH2
CAS No.	2252208-09-4
Molecular Formula	C82H168N2O27
Molecular Weight	~1646.2 g/mol
Synonyms	α-Amino-ω-(2-aminoethyl)amido-poly(oxy-1,2-ethanediyl); Amine-PEG27-Ethylenediamine; NH2-PEG27-NHCH2CH2NH2; Heterobifunctional PEG27 Amine; PEG 1200 Diamine Derivative; 27-mer PEG Diamine; Jeffamine ED-2001 Analog (PEG-based); Poly(ethylene glycol) bis(3-aminopropyl) terminated (approx. n=27)
EINECS	Contact for details

Quality Control

Every batch of H2N-PEG27-CH2CH2NH2 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from NMR (¹H and ¹³C), HPLC for purity and impurity profiling, and titration for amine value determination. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, recommended storage temperature is -20°C to -10°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Average Molecular Weight	1600 - 1700 g/mol
Amine Value	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.