Description

Boc-Aminooxy-Peg5-Amine CAS NO 2250216-94-3 is a heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected aminooxy group and a primary amine terminus. This compound is a critical reagent for the site-specific conjugation of biomolecules, enabling the creation of stable oxime bonds with carbonyl-containing targets. It is primarily utilized by researchers and process developers in the pharmaceutical and biotech industries for advanced drug delivery system development, bioconjugation, and proteomics applications.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, or peptides via oxime ligation for the production of antibody-drug conjugates (ADCs) and other biotherapeutics.
• PEGylation Reagent: Used to introduce a hydrophilic PEG spacer to drugs, peptides, or surfaces to improve solubility, stability, and pharmacokinetic profiles.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker for coupling aldehydes or ketones from glycoproteins or oxidized carbohydrates to amine-containing molecules.
• Surface Functionalization: Modification of nanoparticles, quantum dots, or solid supports to create amine-reactive surfaces for further immobilization chemistry.
• Proteomics Research: Tool for chemical proteomics, including the labeling and enrichment of carbonyl-modified proteins or glycoproteins.
• Linker for Solid-Phase Synthesis: Incorporation as a cleavable or functionalizable spacer in solid-phase peptide synthesis (SPPS) and combinatorial chemistry.

Basic Information

Product Name	Boc-Aminooxy-Peg5-Amine
CAS No.	2250216-94-3
Molecular Formula	C22H46N2O9
Molecular Weight	482.61 g/mol
Synonyms	1-Amino-3,6,9,12,15-pentaoxaheptadecan-17-yl (tert-butoxycarbonyl)aminooxycarbamate; Boc-NH-O-PEG5-NH2; tert-Butyl N-(17-amino-3,6,9,12,15-pentaoxaheptadec-17-yloxy)carbamate; Aminooxy-PEG5-amine Boc-protected; Boc-Aminooxy-PEG5-NH2; Boc-protected Aminooxy-Pentaethylene glycol-amine; Heterobifunctional PEG linker Boc-Aminooxy-PEG-amine
EINECS	Contact for details

Quality Control

Our Boc-Aminooxy-Peg5-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) with lot-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.