Description

Mal-Peg1-Val-Cit-Pab-Pnp is a specialized, heterobifunctional linker-payload intermediate designed for the synthesis of antibody-drug conjugates (ADCs). This compound matters because it integrates a maleimide group for site-specific conjugation to cysteine residues on antibodies with a protease-cleavable Val-Cit-PAB linker and a p-nitrophenyl (PNP) ester for efficient payload attachment. Pharmaceutical researchers and process development scientists in the biopharmaceutical industry need this high-purity intermediate to develop targeted cancer therapies with controlled drug-to-antibody ratios (DAR) and optimized therapeutic windows.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: As a critical building block for constructing stable, cleavable linker-payload systems.
• Bioconjugation Research: For developing novel targeted therapeutics by linking cytotoxic agents to monoclonal antibodies or other targeting proteins.
• Prodrug Development: In the design of enzyme-activated prodrugs that release active pharmaceutical ingredients (APIs) in specific physiological environments.
• Chemical Biology Tool: For studying protein function and interaction through site-specific labeling techniques.
• Process Development & Scale-up: Used in the optimization and manufacturing processes for next-generation biopharmaceuticals.
• Preclinical & Clinical Candidate Development: Serves as a key intermediate in the research and development pipeline for novel oncology therapeutics.

Basic Information

Product Name	Mal-Peg1-Val-Cit-Pab-Pnp
CAS No.	2249935-92-8
Molecular Formula	C₃₄H₄₅N₇O₁₂
Molecular Weight	719.77 g/mol
Synonyms	Maleimide-PEG1-Valine-Citrulline-PAB-PNP Ester; MC-Val-Cit-PAB-PNP; N-(2-((2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)carbonylamino)ethyl)-N-((S)-1-(((S)-1-((4-((4-nitrophenoxy)carbonyl)benzyl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-(2-((2-aminoethoxy)carbonylamino)ethylamino)-1-oxobutan-2-yl)succinamate; ADC Linker-Payload Intermediate; Valine-Citrulline p-Aminobenzyloxycarbonyl PNP Ester Maleimide Conjugate; Protease-Cleavable ADC Linker
EINECS	Contact for details

Quality Control

Our Mal-Peg1-Val-Cit-Pab-Pnp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive bioconjugation chemistry. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation suitable for preclinical and clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.