Description

Dalbavancin Hydrochloride CAS NO 2227366-51-8 is a semi-synthetic lipoglycopeptide antibiotic, a second-generation derivative of teicoplanin. It is a critical active pharmaceutical ingredient (API) valued for its potent and prolonged bactericidal activity against Gram-positive pathogens, including multidrug-resistant strains. This compound is essential for pharmaceutical manufacturers developing long-acting injectable antibiotic formulations for the treatment of acute bacterial skin and skin structure infections (ABSSSI).

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Long-Acting Antibiotic Development: Key component in R&D for novel drug delivery systems that provide sustained therapeutic effect from a single dose.
• Treatment of Gram-Positive Infections: Specifically targeted for manufacturing drugs to treat ABSSSI caused by Staphylococcus aureus (including MRSA) and Streptococcus pyogenes.
• Hospital-Acquired Infection Therapeutics: Used in the production of antibiotics for serious infections prevalent in healthcare settings.
• Reference Standard: Serves as a high-purity chemical standard for analytical testing, quality control, and regulatory submissions.
• Research & Development: Utilized in microbiological studies, mechanism of action research, and development of new combination therapies.

Basic Information

Product Name	Dalbavancin Hydrochloride
CAS No.	2227366-51-8
Molecular Formula	C88H100Cl2N10O28 • xHCl
Molecular Weight	~1816.1 g/mol (free base)
Synonyms	Dalbavancin HCl; BI 397; MDL 63,246; A-A1; (3S,6R,15R,18R,21S,24S,28R,32S,33R,36S,39R)-33-[(2R,3R,4R,5S,6R)-4-Amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-6,15,18,21,24,33,36-heptahydroxy-3-[(1R,2R)-1-hydroxy-2-[(2R,4S,5S,6S)-4-hydroxy-5-[(2R,4S,5S,6S)-4-hydroxy-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxypropyl]-32-methoxy-39-[[(2R)-1-oxo-1-[[(1S,2S)-1-phenyl-2-(phosphonoamino)propyl]amino]propan-2-yl]amino]-1,4,7,10,13,16,19,22,25,30,34,37-dodecaoxa-2,5,8,11,14,17,20,23,26,31,35,38-dodecazaoctatetracontan-40-oic acid hydrochloride; Dalvance (brand name)
EINECS	Contact for details

Quality Control

Our Dalbavancin Hydrochloride is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical development and manufacturing. We provide comprehensive Certificates of Analysis (COA) that include data for identity, purity, potency, and specified impurities, supporting compliance with ICH Q7 guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Bacterial Endotoxins	< 1.0 EU/mg (where applicable)
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.