Description

Thiol-Peg12-Acid CAS NO 2211174-73-9 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive thiol group at one terminus and a carboxylic acid group at the other. This molecular architecture is critical for creating stable, site-specific bioconjugates and functionalized materials through orthogonal click chemistry and amide bond formation. It is an essential building block for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the precise modification of peptides, proteins, surfaces, and nanoparticles.

Application

• Bioconjugation and Linker Chemistry: Site-specific coupling of biomolecules (e.g., antibodies, peptides) to drugs, dyes, or solid supports via thiol-maleimide or thiol-haloacetyl chemistry, with the PEG spacer providing solubility and reducing steric hindrance.
• PEGylation Reagent: Used to introduce PEG chains onto therapeutic proteins or nanoparticles to enhance pharmacokinetic properties, such as increased circulation half-life and reduced immunogenicity.
• Surface Functionalization: Creating self-assembled monolayers (SAMs) on gold or other metal surfaces via the thiol group, with the terminal acid group available for further covalent attachment of biomolecules or polymers.
• Hydrogel and Biomaterial Synthesis: Serving as a crosslinker or functional component in the fabrication of hydrogels and biocompatible materials for drug delivery and tissue engineering applications.
• Diagnostic Reagent Synthesis: Conjugation of targeting ligands to signal-generating molecules (e.g., enzymes, fluorophores) for use in immunoassays and biosensors.
• Polymer and Dendrimer Modification: Introducing functional handles onto polymer backbones or dendrimer surfaces for creating multifunctional nanocarriers.

Basic Information

Product Name	Thiol-Peg12-Acid
CAS No.	2211174-73-9
Molecular Formula	C27H56O14S
Molecular Weight	636.8 g/mol
Synonyms	HS-PEG12-COOH; α-Thiol-ω-carboxy PEG12; 1-Mercapto-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatetracontan-48-oic Acid; SH-PEG12-Acid; Thiol-PEG12-Acetic Acid; 12-Amino-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxanonatriacontanoic Acid (related); Thiol-Polyethylene Glycol12-Acid; Heterobifunctional PEG 12, Thiol and Acid
EINECS	Contact for details

Quality Control

Our Thiol-Peg12-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation of the thiol group and minimize moisture absorption. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Thiol Titration)	≥ 90%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC)	600 - 680 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.