Description

Mal-Peg4-Glu(Oh)-Nh-m-Peg24 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a carboxylic acid group, separated by a branched PEG spacer. This compound is engineered for high-efficiency bioconjugation, enabling the stable, site-specific coupling of biomolecules such as peptides, proteins, and antibodies. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced drug delivery system formulation, where precise linker chemistry is critical.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via the maleimide-thiol chemistry.
• PEGylation of Therapeutic Proteins: To enhance solubility, stability, and circulation half-life of biologics by conjugating through amine groups.
• Diagnostic Probe Conjugation: For linking fluorescent dyes, enzymes, or other reporter molecules to targeting ligands (e.g., peptides, antibodies) in assay development.
• Surface Functionalization: Modifying nanoparticles, biosensors, or microarray surfaces to create reactive sites for biomolecule immobilization.
• Cross-linking Agent: For creating stable bridges between different biomolecules or between a biomolecule and a material surface.
• Building Block for Complex Architectures: Used in the synthesis of multi-arm PEGs or dendritic structures for sophisticated drug delivery platforms.

Basic Information

Product Name	Mal-Peg4-Glu(Oh)-Nh-m-Peg24
CAS No.	2204309-09-9
Molecular Formula	CnH2n+2On+1 (Contact for exact formula)
Molecular Weight	~2000 g/mol (Contact for exact MW)
Synonyms	Maleimide-PEG4-Glu(Oh)-NH-m-PEG24; MAL-PEG4-GLU(OH)-NH-m-PEG24; mPEG24-Mal; Heterobifunctional PEG Maleimide Carboxylic Acid; Maleimide-PEG-acid; 3-Maleimidopropionic acid-PEG24-COOH; NHS-PEG-MAL (related); PEG-based crosslinker, Maleimide-PEG4-Glutamate derivative
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Glu(Oh)-Nh-m-Peg24 is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and functional group assay, NMR for structural confirmation, and MS for molecular weight verification. We provide comprehensive Certificates of Analysis (COA) with all shipments to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Maleimide Content	≥ 90% of theoretical
Molecular Weight (MS)	Within ± 5% of theoretical
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.