Description

Bdp Fl-Peg4-(4E)-Tco CAS NO 2183473-16-5 is a high-purity, bifunctional chemical linker featuring a BODIPY FL fluorophore, a tetraethylene glycol (PEG4) spacer, and a trans-cyclooctene (TCO) moiety. This compound is engineered for advanced bioorthogonal conjugation, enabling highly specific and efficient labeling of biomolecules in complex biological systems. It is an essential reagent for researchers and developers in the fields of bioconjugation, chemical biology, and the development of next-generation diagnostics and therapeutics.

Application

• Bioorthogonal Labeling and Imaging: Utilized in live-cell and in vivo imaging via the rapid and selective inverse electron-demand Diels-Alder (IEDDA) reaction between the TCO group and tetrazines.
• Antibody-Drug Conjugate (ADC) Development: Serves as a critical fluorescent linker-payload for constructing and tracking ADCs, facilitating drug-to-antibody ratio (DAR) analysis and pharmacokinetic studies.
• Proteomics and Biomarker Discovery: Enables fluorescent tagging of proteins, peptides, and other biomolecules for detection, purification, and analysis in gel electrophoresis and microscopy.
• Diagnostic Assay Development: Used to create highly sensitive fluorescent probes and sensors for immunoassays, flow cytometry, and in situ hybridization.
• Polymer and Material Science: Acts as a functional monomer or cross-linker for synthesizing smart, fluorescently tagged hydrogels, nanoparticles, and polymeric materials.
• Chemical Biology Tool Development: A key building block for creating novel chemical probes to study biological processes, enzyme activity, and molecular interactions.

Basic Information

Product Name	Bdp Fl-Peg4-(4E)-Tco
CAS No.	2183473-16-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BDP FL-PEG4-TCO; BODIPY® FL-PEG4-trans-Cyclooctene; 4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Propionic Acid, (4E)-TCO-PEG4-amide; BODIPY FL C5-(4E)-TCO-PEG4; BDP FL TCO PEG4; BODIPY® FL TCO PEG4 Conjugate; BDP-FL-PEG4-(4E)-TCO; BODIPY FL-PEG4-trans-Cyclooctene Conjugate
EINECS	Contact for details

Quality Control

Every batch of Bdp Fl-Peg4-(4E)-Tco is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and performance. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality commitment aligns with the standards required for research and development in pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red solid or film
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.