Description

Mal-Amido-Peg9-Amine Tfa Salt is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a maleimide group for thiol conjugation and a terminal amine group for further chemical modification, presented as a trifluoroacetate (TFA) salt. This compound is critical for creating stable, site-specific bioconjugates and functionalized materials with controlled linker length and solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as antibody-drug conjugate (ADC) development, protein and peptide modification, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Construction: The maleimide group enables stable thiol-maleimide chemistry for attaching cytotoxic drugs to antibodies via engineered cysteine residues.
• Protein and Peptide PEGylation: Used to modify therapeutic proteins and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Surface Functionalization for Biosensors and Diagnostics: The amine terminus allows for covalent attachment to activated surfaces (e.g., glass, gold, polymers) to create bio-interfaces for assay development.
• Nanoparticle and Liposome Conjugation: Facilitates the functionalization of drug delivery carriers with targeting ligands or imaging agents.
• Crosslinking Agent for Hydrogel Formation: Serves as a heterobifunctional crosslinker in the synthesis of smart hydrogels for tissue engineering and controlled release.
• Small Molecule Prodrug Synthesis: Enables the attachment of drug molecules to solubilizing PEG chains or targeting vectors via the reactive amine group.

Basic Information

Product Name	Mal-Amido-Peg9-Amine Tfa Salt
CAS No.	2182602-22-6
Molecular Formula	C31H55F3N4O13
Molecular Weight	748.79 g/mol
Synonyms	Maleimide-PEG9-Amine TFA Salt; MAL-PEG9-NH2.TFA; 3-({2-[2-(2-{2-[2-(2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}propyl)-1H-pyrrole-2,5-dione trifluoroacetate; N-(Amino-PEG9)-maleimide TFA Salt; 1-[11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9-trioxaundec-1-yl]-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-amine trifluoroacetate; Amino-PEG9-Maleimide TFA Salt; mPEG9-MAL-amine TFA; Heterobifunctional PEG linker MAL-PEG9-NH2 TFA
EINECS	Contact for details

Quality Control

Our Mal-Amido-Peg9-Amine Tfa Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for bioconjugation and pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Assay (Maleimide)	≥ 90%
Functional Group Assay (Amine)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.