Description

Propargyl-Peg8-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and an N-hydroxysuccinimide (NHS) ester for efficient amine coupling. This compound is essential for creating stable, hydrophilic spacers in bioconjugation strategies, enabling the precise assembly of complex biomolecular architectures. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science, where controlled, site-specific labeling and cross-linking are required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Serves as a hydrophilic linker to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• PEGylation of Peptides and Proteins: Used to attach PEG chains to therapeutic biomolecules via amine groups, enhancing stability and reducing immunogenicity.
• Surface Functionalization and Biosensor Fabrication: Enables the controlled immobilization of biomolecules (e.g., proteins, oligonucleotides) onto sensor surfaces, chips, or nanoparticles via click chemistry.
• Polymer and Dendrimer Synthesis: Acts as a building block for constructing functionalized, branched, or cross-linked polymeric networks with tailored properties.
• Fluorescent Probe and Diagnostic Reagent Preparation: Facilitates the site-specific labeling of antibodies, enzymes, or other proteins with fluorescent dyes or other reporter molecules.
• Hydrogel Formation for Drug Delivery and Tissue Engineering: Used as a cross-linking agent to create biocompatible, PEG-based hydrogels with controlled release properties.

Basic Information

Product Name	Propargyl-Peg8-Nhs Ester
CAS No.	2182601-74-5
Molecular Formula	C33H57NO15
Molecular Weight	707.8 g/mol
Synonyms	Propargyl-PEG8-NHS ester; Propargyl-PEG8-NHS ester; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12,15,18,21,24-octaoxahexacos-25-yn-26-oate; 25-Propargyl-3,6,9,12,15,18,21,24-octaoxapentacosanoic acid N-succinimidyl ester; Propargyl-O2-(CH2CH2O)8-CH2CH2-COO-NHS; Alkyne-PEG8-NHS ester; NHS-PEG8-Propargyl; Propargyl-PEG8-NHS
EINECS	Contact for details

Quality Control

Our Propargyl-Peg8-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and production needs in compliance with cGMP and ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.