Description

Biotin-Peg8-Alcohol CAS NO 2182601-20-1 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a biotin moiety and a terminal hydroxyl group. This bifunctional linker is critical for creating stable, site-specific conjugates in biopharmaceutical development and diagnostic applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug delivery systems, surface modification, and the development of targeted therapeutics and assays.

Application

• ADC (Antibody-Drug Conjugate) Linker: Serves as a hydrophilic, flexible spacer to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• PEGylation Reagent: Used to modify peptides, proteins, and nanoparticles with biotin tags, enhancing stability and enabling downstream purification or detection via streptavidin.
• Diagnostic Probe Synthesis: A key building block for constructing biotinylated probes used in ELISA, lateral flow assays, and other immunoassay platforms.
• Surface Functionalization: Employed to create biotin-coated surfaces on chips, beads, or plates for capturing streptavidin-conjugated molecules in biosensor and microarray technologies.
• Drug Delivery Carrier: Incorporated into micelles, liposomes, or polymer-drug conjugates to add targeting capabilities via the biotin-streptavidin interaction.
• Chemical Biology Tool: Facilitates the study of protein-protein interactions and cellular processes through biotin-based labeling and pull-down experiments.

Basic Information

Product Name	Biotin-Peg8-Alcohol
CAS No.	2182601-20-1
Molecular Formula	C37H68N4O13S
Molecular Weight	809.0 g/mol
Synonyms	Biotin-PEG8-OH; Biotin-PEG8-alcohol; Biotinylated PEG8 alcohol; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide; Biotin-8-Unit PEG Alcohol; Biotin-Polyethylene Glycol8-OH; Biotin-PEG8 linker
EINECS	Contact for details

Quality Control

Our Biotin-Peg8-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF, water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.