Description

H2N-PEG24-CH2CH2COOtBu is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine and a protected carboxylic acid terminus. This compound is engineered to serve as a critical building block for creating sophisticated bioconjugates and functionalized materials, enabling precise control over solubility, biocompatibility, and spacing. It is essential for researchers and manufacturers in the fields of biopharmaceutical development, advanced drug delivery systems, and nanotechnology who require reliable, well-defined PEG linkers.

Application

• Bioconjugation and Linker Chemistry: Used to conjugate peptides, proteins, antibodies, or small molecule drugs, improving pharmacokinetics and reducing immunogenicity.
• Drug Delivery System Development: A key reagent for synthesizing PEGylated prodrugs and constructing targeted nanocarriers like liposomes and polymeric micelles.
• Surface Functionalization: For modifying nanoparticles, biosensors, and diagnostic assay platforms to enhance stability and introduce specific reactive groups.
• Hydrogel and Biomaterial Synthesis: Acts as a crosslinker or functional component in the creation of biocompatible hydrogels for tissue engineering and controlled release applications.
• Diagnostic Reagent Preparation: Employed in the development of fluorescent probes, contrast agents, and other diagnostic tools requiring water-soluble linkers.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a soluble polymer support or as a component for introducing PEG spacers into synthetic peptides.

Basic Information

Product Name	H2N-PEG24-CH2CH2COOtBu
CAS No.	2170987-96-7
Molecular Formula	C58H117NO27
Molecular Weight	~1244.6 g/mol
Synonyms	Amino-PEG24-t-butyl ester; α-Amino-ω-(t-butoxycarbonylethyl)hexacosaoxatetrapentacontane; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 3-tert-butoxy-3-oxopropanoate; Amine-PEG24-C2-acid t-butyl ester; Boc-protected PEG24-amine acid; Heterobifunctional PEG 24-arm amine, acid t-butyl ester
EINECS	Contact for details

Quality Control

Our H2N-PEG24-CH2CH2COOtBu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities like diols and residual solvents. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Molecular Weight Confirmation (MS)	Conforms
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.