Description

Fmoc-n-Amido-Peg24-Acid CAS NO 2170484-59-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive carboxylic acid group and an amine group protected by a fluorenylmethyloxycarbonyl (Fmoc) moiety. This compound is essential for creating precisely engineered, long-chain PEG spacers in bioconjugation and pharmaceutical development, offering superior solubility and reduced immunogenicity. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, peptide synthesis, and advanced drug delivery systems.

Application

• As a versatile linker for the site-specific conjugation of peptides, proteins, and antibodies to drug molecules or surfaces.
• For the synthesis of PEGylated therapeutic agents to enhance pharmacokinetic properties such as circulation half-life and solubility.
• In the development of complex bioconjugates for targeted drug delivery and diagnostic applications.
• As a key building block in solid-phase peptide synthesis (SPPS) for introducing hydrophilic PEG spacers.
• For surface functionalization and the creation of biocompatible coatings in biomedical research.
• In the preparation of ADC (Antibody-Drug Conjugate) linkers to optimize payload release and stability.

Basic Information

Product Name	Fmoc-n-Amido-Peg24-Acid
CAS No.	2170484-59-8
Molecular Formula	C133H217N3O55
Molecular Weight	~2694.1 g/mol
Synonyms	Fmoc-NH-PEG24-COOH; Fmoc-Amine-PEG24-Acid; 24-Amino-3,6,9,12,15,18,21-heptaoxatricosanoic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-PEG24-acid; Fmoc-N-amido-PEG24-acid; Fmoc-NH-(CH2CH2O)24-CH2CH2COOH; N-α-Fmoc-24-amino-4,7,10,13,16,19,22-heptaoxatetracosanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-Amido-Peg24-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, Methylene Chloride

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.