Description

Bis-Peg23-Endo-Bcn CAS NO 2152700-22-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring an endo-BCN (bicyclo[6.1.0]nonyne) group at one terminus. This compound is engineered for efficient, copper-free click chemistry applications, enabling the stable conjugation of biomolecules, nanoparticles, and surfaces under mild, biocompatible conditions. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, advanced drug delivery systems, and diagnostic probe development.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a linker to attach cytotoxic payloads, fluorescent dyes, or other functional molecules to antibodies, proteins, and peptides.
• Nanoparticle and Liposome Functionalization: Facilitates the surface modification of drug carriers for targeted delivery, improving solubility and circulation time.
• Surface Immobilization and Hydrogel Formation: Enables the site-specific attachment of biomolecules to chips, beads, or scaffolds for biosensors, microarrays, and tissue engineering.
• Diagnostic Reagent Synthesis: Critical for creating stable, high-affinity probes for in vitro diagnostics (IVD) and imaging agents.
• Polymer and Biomaterial Modification: Serves as a versatile building block for synthesizing advanced, functionalized polymers with tailored properties.
• Chemical Biology and Proteomics Research: A key tool for labeling and studying biomolecules in live cells and complex biological systems.

Basic Information

Product Name	Bis-Peg23-Endo-Bcn
CAS No.	2152700-22-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	endo-BCN-PEG23-NHS ester; BCN-PEG23-NHS; Bicyclo[6.1.0]nonyne-PEG23-N-hydroxysuccinimide ester; Heterobifunctional PEG linker BCN-PEG-NHS; PEG23 endo-BCN NHS ester; BCN-PEG23-Succinimidyl ester; 23-unit Polyethylene glycol endo-BCN NHS ester; BCN-PEG23-NHS
EINECS	Contact for details

Quality Control

Our Bis-Peg23-Endo-Bcn is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, and water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.