Description

Acid-Peg13-Nhs Ester CAS NO 2152679-62-2 is a heterobifunctional polyethylene glycol (PEG) linker featuring a carboxylic acid group and an N-hydroxysuccinimide (NHS) ester. This compound is engineered to facilitate the stable and efficient conjugation of biomolecules, such as peptides, proteins, and antibodies, to various surfaces or other molecules. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, drug delivery system development, and diagnostic assay production.

Application

• Bioconjugation Reagent: For creating stable amide bonds between amine-containing biomolecules (proteins, antibodies, peptides) and carboxylated surfaces or particles.
• PEGylation Chemistry: Used to introduce a hydrophilic PEG spacer to drugs or proteins, improving solubility, stability, and circulation time in vivo.
• Diagnostic Kit Development: Critical for immobilizing capture antibodies or antigens onto microplates, beads, or biosensor surfaces in ELISA and lateral flow assays.
• Drug Delivery System Fabrication: Enables the functionalization of liposomes, nanoparticles, and polymer-drug conjugates for targeted delivery applications.
• Crosslinking Agent: Serves as a versatile crosslinker for modifying biomaterials, hydrogels, and tissue engineering scaffolds.
• Surface Functionalization: Used to create reactive NHS-ester groups on carboxyl-terminated self-assembled monolayers (SAMs) or chips for SPR and microarray technologies.

Basic Information

Product Name	Acid-Peg13-Nhs Ester
CAS No.	2152679-62-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	α-Acid-ω-NHS-PEG13; Carboxy-PEG13-NHS ester; NHS-PEG13-acid; 15-Aza-3,6,9,12-tetraoxapentadecanoic acid, 14-[(2,5-dioxo-1-pyrrolidinyl)oxy]-14-oxo-; HOOC-PEG13-NHS; NHS-PEG13-COOH; 1-Carboxy-3,6,9,12-tetraoxapentadecan-15-yl 2,5-dioxopyrrolidine-1-carboxylate; PEG13-based heterobifunctional crosslinker
EINECS	Contact for details

Quality Control

Our Acid-Peg13-Nhs Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation work. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester moiety is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Assay (Acid)	≥ 90%
Functional Group Assay (NHS Ester)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.