Description

D-Biotin-Peg6-Thalidomide CAS NO 2144775-48-2 is a high-purity, bifunctional PROTAC linker-conjugate designed for advanced chemical biology and drug discovery applications. This compound is engineered to enable the targeted degradation of proteins by linking a thalidomide-based E3 ligase recruiter to a biotin moiety via a flexible, hydrophilic polyethylene glycol (PEG6) spacer. It is an essential research tool for scientists in pharmaceutical R&D, chemical biology, and proteomics who require reliable, well-characterized building blocks for developing novel therapeutic modalities.

Application

• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a critical linker component for constructing bifunctional molecules that recruit E3 ubiquitin ligases to target proteins for degradation.
• Chemical Biology Probes: Used to create biotinylated probes for studying protein-protein interactions, target engagement, and cellular localization via streptavidin-based pulldown assays.
• Targeted Protein Degradation Research: Facilitates the exploration of novel "undruggable" targets in oncology, neurodegenerative diseases, and inflammatory disorders.
• Pre-Clinical Drug Discovery: Employed in the synthesis and optimization of potential therapeutic candidates utilizing the Cereblon (CRBN)-mediated degradation pathway.
• Bioconjugation and ADC Development: The PEG6 spacer and biotin group make it suitable for creating conjugates with improved solubility and pharmacokinetic properties.

Basic Information

Product Name	D-Biotin-Peg6-Thalidomide
CAS No.	2144775-48-2
Molecular Formula	C₄₇H₆₆N₈O₁₃S
Molecular Weight	983.14 g/mol
Synonyms	Biotin-PEG6-Thalidomide; Thalidomide-PEG6-Biotin; Biotin-PEG6-Cereblon Ligand; E3 Ligase Ligand-PEG6-Biotin Conjugate; (S)-Biotin-PEG6-(S)-Thalidomide; PROTAC Linker Conjugate; CRBN Recruiter-PEG6-Biotin; Biotinylated Thalidomide Derivative
EINECS	Contact for details

Quality Control

Every batch of D-Biotin-Peg6-Thalidomide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for research-grade and pre-clinical materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.