Description

Biotin-Peg8-Acid CAS NO 2143964-62-7 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin moiety for affinity capture and a terminal carboxylic acid for covalent conjugation. This compound is essential for creating stable, site-specific bioconjugates with enhanced solubility and reduced immunogenicity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostics, and biotechnology sectors for developing advanced drug delivery systems, diagnostic probes, and affinity purification matrices.

Application

• Conjugation reagent for the biotinylation of antibodies, proteins, peptides, and nanoparticles for use in diagnostic assays (ELISA, lateral flow) and affinity chromatography.
• Critical component in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics, where the PEG spacer improves pharmacokinetics.
• Surface functionalization agent for biosensors and microarray chips to enable specific biomolecular capture and detection.
• Building block for constructing complex drug delivery platforms, including polymer-drug conjugates and liposomal systems.
• Tool compound in proteomics and molecular biology research for pull-down experiments and protein interaction studies.
• Intermediate in the preparation of fluorescent or radioactive probes for in vivo imaging and biodistribution studies.

Basic Information

Product Name	Biotin-Peg8-Acid
CAS No.	2143964-62-7
Molecular Formula	C37H68N4O14S
Molecular Weight	825.0 g/mol
Synonyms	Biotin-PEG8-acid; Biotin-PEG8-COOH; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(2-(2-(2-(2-(2-(carboxymethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)pentanamide; Biotinamido-PEG8-acid; Biotinylated PEG8 acid; Biotin-PEG8-Propionic Acid; Biotin-PEG8-CH2CH2COOH
EINECS	Contact for details

Quality Control

Our Biotin-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements for pharmaceutical development (GMP-grade available) or research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.