Description

Tco-Peg3-Acid CAS NO 2141981-86-2 is a specialized bifunctional linker molecule featuring a terminal TCO (trans-cyclooctene) group and a carboxylic acid, connected by a triethylene glycol (PEG3) spacer. This compound is essential for bioorthogonal click chemistry, enabling rapid, selective, and catalyst-free conjugation under mild physiological conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and diagnostics industries for applications such as antibody-drug conjugate (ADC) development, protein labeling, and surface functionalization of nanoparticles.

Application

• Antibody-Drug Conjugate (ADC) Development: Used as a key linker for site-specific conjugation of cytotoxic payloads to monoclonal antibodies via strain-promoted alkyne-azide cycloaddition (SPAAC) with tetrazine-modified molecules.
• Protein and Peptide Labeling: Facilitates the attachment of fluorophores, biotin, or other probes to biomolecules for imaging, detection, and pull-down assays.
• Surface Functionalization: Enables the modification of nanoparticles, liposomes, and other material surfaces with targeting ligands or therapeutic agents.
• Prodrug Synthesis: Serves as a cleavable linker in the design of prodrugs that release active agents upon encountering specific biological triggers.
• Polymer Chemistry: Acts as a functional monomer or cross-linker for creating smart, responsive hydrogels and polymeric materials.
• Diagnostic Reagent Formulation: Incorporated into the design of contrast agents and molecular probes for in vivo imaging and diagnostic kits.

Basic Information

Product Name	Tco-Peg3-Acid
CAS No.	2141981-86-2
Molecular Formula	C19H32N2O6
Molecular Weight	384.47 g/mol
Synonyms	trans-Cyclooctene-PEG3-acid; (E)-Cyclooct-4-enyl 2,5,8,11-tetraoxatetradecan-14-oate; TCO-PEG3-COOH; TCO-PEG3-propionic acid; 2,5,8,11-Tetraoxatetradecan-14-oic acid, (E)-cyclooct-4-enyl ester; TCO-triethyleneglycol-acid; TCO-PEG3-Acid; Acid-PEG3-TCO
EINECS	Contact for details

Quality Control

Our Tco-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioorthogonal applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.