Description

Sco-Peg2-Maleimide CAS NO 2141976-23-8 is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group on one terminus and a protected thiol-reactive group on the other. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and protein-polymer therapeutics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and controlled crosslinking strategies.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via cysteine residues.
• Protein-Polymer Conjugation: PEGylation of therapeutic proteins to enhance pharmacokinetic properties such as solubility and circulation half-life.
• Peptide and Small Molecule Modification: Functionalization of peptides or drug molecules with PEG chains for improved bioavailability.
• Surface Immobilization: Covalent attachment of biomolecules (e.g., antibodies, enzymes) to sensor chips or nanoparticles for diagnostic and biosensing applications.
• Hydrogel Formation: Crosslinking agent in the synthesis of biocompatible hydrogels for drug delivery and tissue engineering.
• Bioconjugation Research: A versatile tool in chemical biology for creating defined biomolecular constructs.

Basic Information

Product Name	Sco-Peg2-Maleimide
CAS No.	2141976-23-8
Molecular Formula	C17H27NO8S
Molecular Weight	405.46 g/mol
Synonyms	1-[2-[2-[2-[2-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 2,2-dimethyl-1,3-thiazolidine-4-carboxylate; Maleimide-PEG2-SCO; SCO-PEG2-MAL; 2,2-Dimethyl-1,3-thiazolidine-4-carboxylic Acid (2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl PEG Ester; Thiazolidine-PEG2-Maleimide; Heterobifunctional PEG Linker, Maleimide-SCO
EINECS	Contact for details

Quality Control

Our Sco-Peg2-Maleimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, moderately soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.