Description

Clindamycin-13C-D3 is a high-purity, isotopically labeled analog of the antibiotic clindamycin, specifically designed for use as an internal standard in quantitative mass spectrometry. This compound is essential for ensuring the accuracy and reliability of analytical methods in pharmaceutical research and development. It is primarily used by scientists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and clinical diagnostics sectors for pharmacokinetic studies, bioanalytical method validation, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of clindamycin and its metabolites in complex biological matrices such as plasma, serum, and tissue homogenates.
• Bioanalytical Method Development & Validation (FDA/EMA Guidelines): Used to establish robust, sensitive, and specific analytical methods for drug monitoring and pharmacokinetic studies.
• Metabolite Profiling and Identification: Aids in the structural elucidation of clindamycin metabolites in drug metabolism and pharmacokinetics (DMPK) research.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for clindamycin-based drug products to ensure batch-to-batch consistency.
• Clinical Research: Enables accurate measurement of drug concentrations in patient samples during clinical trials for therapeutic drug monitoring.
• Forensic and Anti-Doping Analysis: Provides a reliable reference for detecting and quantifying clindamycin in forensic toxicology and sports doping control.

Basic Information

Product Name	Clindamycin-13C-D3
CAS No.	2140264-63-5
Molecular Formula	C18H3013C3D3ClN2O5S
Molecular Weight	~ 452.5 g/mol (labeled)
Synonyms	Clindamycin (methyl-13C3, 2,2,3,3,4,4-d6); (2S,4R)-N-[(1S,2S)-2-Chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide-13C3-d3; 7(S)-Chloro-7-deoxylincomycin-13C3-d3; Isotopically Labeled Clindamycin; Clindamycin Internal Standard; Clindamycin-IS; [13C3,D3]-Clindamycin
EINECS	Contact for details

Quality Control

Every batch of Clindamycin-13C-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), isotopic enrichment (typically ≥99 atom % 13C, ≥98 atom % D), and absence of unlabeled clindamycin. Our quality commitment ensures compliance with the stringent requirements of analytical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (13C)	≥ 99 atom %
Isotopic Purity (D)	≥ 98 atom %
Chemical Purity (Unlabeled Clindamycin)	≤ 0.5%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.