Description

Fmoc-Peg3-Ch2Co2-Nhs CAS NO 2128735-25-9 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and an acid-labile Fmoc-protected amine. This compound matters as a critical building block for the controlled synthesis of peptide-PEG conjugates and complex biomaterials, enabling precise spacing and solubility enhancement. It is primarily needed by researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics for creating drug delivery systems, diagnostic reagents, and advanced hydrogel scaffolds.

Application

• Peptide-PEG Conjugate Synthesis: Used as a spacer/linker to introduce PEG chains onto peptides or proteins via NHS-ester chemistry, improving pharmacokinetics.
• Controlled Drug Delivery Systems: Facilitates the construction of cleavable linkers in antibody-drug conjugates (ADCs) and prodrugs, where the Fmoc group allows for selective deprotection.
• Biomaterial and Hydrogel Fabrication: Serves as a crosslinking agent for creating biocompatible networks with tailored degradation profiles for tissue engineering.
• Surface Functionalization: Enables the PEGylation of nanoparticles, chips, or other solid supports to create non-fouling surfaces with reactive handles for further coupling.
• Proteomics Research: Acts as a reagent for labeling or immobilizing biomolecules while maintaining solubility and reducing non-specific binding.
• Diagnostic Reagent Development: Utilized in the design of fluorescent or enzymatic probes where a hydrophilic PEG spacer is required to minimize steric hindrance.

Basic Information

Product Name	Fmoc-Peg3-Ch2Co2-Nhs
CAS No.	2128735-25-9
Molecular Formula	C33H42N2O11
Molecular Weight	642.70 g/mol
Synonyms	Fmoc-N-amido-PEG3-acid NHS ester; N-(9-Fluorenylmethoxycarbonyl)-3,6,9-trioxaundecanedioic acid 11-(N-succinimidyl ester); 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,6,9-trioxaundecanedioic acid 11-(2,5-dioxo-1-pyrrolidinyl) ester; Fmoc-PEG3-NHS Ester; Fmoc-NH-PEG3-NHS; Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid NHS ester; Fmoc-Amino-PEG3-acetic Acid NHS Ester; 2,5-Dioxopyrrolidin-1-yl 17-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4,7,10,13-tetraoxaheptadecanoate
EINECS	Contact for details

Quality Control

Our Fmoc-Peg3-Ch2Co2-Nhs is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with high-grade research and cGMP starting material standards. Comprehensive Certificates of Analysis (COA) detailing purity, moisture content, and NMR/LCMS characterization are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a freezer. This product is hygroscopic (moisture-sensitive) and the NHS ester moiety is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.