Description

Butyne-Dota is a specialized bifunctional chelating agent designed for advanced radiopharmaceutical applications. This compound is critical for the stable conjugation of diagnostic or therapeutic radionuclides to targeting vectors like peptides and antibodies. It is primarily utilized by researchers and manufacturers in the fields of nuclear medicine, molecular imaging, and targeted radiotherapy development, where precise tumor targeting and imaging are paramount.

Application

• Radiopharmaceutical Precursor: Serves as a key building block for synthesizing novel radiolabeled compounds for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
• Theranostic Agent Development: Enables the creation of dual-purpose agents that combine diagnostic imaging and targeted radiation therapy, particularly in oncology.
• Bioconjugation Linker: Used to attach radionuclides (e.g., Gallium-68, Lutetium-177) to biomolecules like antibodies, peptides, or small molecules via its reactive alkyne and chelating groups.
• Research Chemical: Employed in academic and industrial R&D for exploring new chelation chemistry and improving the pharmacokinetics of radiometal-based drugs.
• Kit Formulation Component: Can be integrated into cold kits for the convenient, on-site preparation of radiopharmaceuticals in clinical settings.

Basic Information

Product Name	Butyne-Dota
CAS No.	2125661-62-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2,2',2''-(10-(2-Butyn-1-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic Acid; Butynyl-DOTA; 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid-10-(2-butynyl) derivative; DOTA-Butyne; Butyne-DOTA chelator; Bifunctional DOTA alkyne
EINECS	Contact for details

Quality Control

Our Butyne-Dota is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is hygroscopic and should be handled in a dry environment to prevent moisture uptake. Allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.