Description

Dspe-Peg4-Acid CAS NO 2112738-58-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a distearoylphosphatidylethanolamine (DSPE) lipid anchor and a terminal carboxylic acid group. This compound is engineered to serve as a critical linker and functionalization agent in advanced nanomaterial synthesis and bioconjugation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for creating targeted drug delivery systems, diagnostic agents, and novel biomaterials.

Application

• Lipid Nanoparticle (LNP) Formulation: As a key functionalizable component (PEG-lipid) for modulating surface properties, enhancing stability, and enabling targeted delivery in mRNA and siRNA therapeutics.
• Liposome and Micelle Functionalization: For the covalent attachment of targeting ligands (e.g., antibodies, peptides) or imaging probes to the surface of nanocarriers via the terminal carboxylic acid group.
• Bioconjugation and Crosslinking: Acting as a heterobifunctional crosslinker to bridge lipid membranes with amine-containing biomolecules, such as proteins or peptides, for creating stable complexes.
• Surface Modification of Nanomaterials: To impart stealth properties (PEGylation) and introduce reactive sites for further chemistry on quantum dots, iron oxide nanoparticles, or other inorganic cores.
• Hydrogel and Biomaterial Synthesis: As a polymerizable or crosslinking unit in the development of biocompatible and functional hydrogels for tissue engineering and controlled release applications.
• Diagnostic Probe Development: For constructing advanced contrast agents by linking lipid-based carriers to chelators or fluorescent dyes.

Basic Information

Product Name	Dspe-Peg4-Acid
CAS No.	2112738-58-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]; DSPE-PEG(2000)-COOH; DSPE-PEG2k-Acid; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] carboxylic acid; DSPE-PEG(4)-Acid; Distearoylphosphatidylethanolamine-PEG4-Carboxylic Acid; PEGylated DSPE Acid; Lipid-PEG-COOH
EINECS	Contact for details

Quality Control

Our Dspe-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, critical impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Acid Value (Titration)	Contact for details
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.