Description

Dspe-Peg4-Dbco CAS NO 2112738-14-2 is a heterobifunctional crosslinker designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and developers requiring precise, efficient, and bio-orthogonal coupling of biomolecules, such as lipids, peptides, and oligonucleotides. It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic sectors for drug delivery system development, surface functionalization, and the creation of complex biomolecular assemblies.

Application

• Lipid Nanoparticle (LNP) Functionalization: Conjugation of targeting ligands or stealth polymers to lipid-based drug delivery carriers for mRNA and siRNA therapeutics.
• Surface Modification: Immobilization of biomolecules onto chips, beads, or other solid supports for biosensor and microarray development.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Facilitating the stable attachment of cytotoxic payloads to monoclonal antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Polymer-Protein Conjugation: Site-specific PEGylation or modification of proteins to enhance stability, solubility, and pharmacokinetic profiles.
• Probe and Diagnostic Reagent Synthesis: Creating fluorescent, biotinylated, or other labeled probes for cellular imaging and in vitro diagnostics (IVD).
• Hydrogel and Biomaterial Crosslinking: Forming biocompatible networks for tissue engineering scaffolds and controlled release matrices.

Basic Information

Product Name	Dspe-Peg4-Dbco
CAS No.	2112738-14-2
Molecular Formula	C73H128N4O19P
Molecular Weight	1413.8 g/mol
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-PEG4-DBCO; DSPE-PEG4-Dibenzocyclooctyne; DBCO-PEG4-DSPE; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000]-Dibenzocyclooctyne derivative; Phospholipid-PEG4-DBCO; Lipid-PEG4-DBCO conjugate; Click chemistry lipid reagent; SPAAC crosslinker lipid
EINECS	Contact for details

Quality Control

Our Dspe-Peg4-Dbco is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation workflows. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in chloroform, DMSO, DMF; partially soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.