Description

Dspe-Peg5-Propargyl CAS NO 2112737-93-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a distearoylphosphatidylethanolamine (DSPE) lipid anchor and a terminal propargyl group. This compound is a critical building block for the site-specific conjugation of biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing advanced drug delivery systems, such as targeted liposomes and lipid nanoparticles (LNPs).

Application

• Lipid Nanoparticle (LNP) Functionalization: Conjugation of targeting ligands (e.g., antibodies, peptides) or imaging agents to the surface of LNPs for targeted drug delivery and diagnostics.
• PEGylated Liposome Engineering: Creating stealth liposomes with a reactive handle for post-insertion of functional molecules to enhance circulation time and target specificity.
• Bioconjugation & Probe Synthesis: Serving as a linker to attach azide-containing drugs, fluorescent dyes, or other payloads to lipid-based platforms for therapeutic and research applications.
• Surface Modification of Biomaterials: Introducing bio-orthogonal reactive groups onto lipid-coated surfaces or matrices for subsequent functionalization in biosensor and tissue engineering platforms.
• mRNA Vaccine & Therapeutic Carrier Development: A key component in the design of next-generation, targeted delivery vehicles for nucleic acid-based therapies.

Basic Information

Product Name	Dspe-Peg5-Propargyl
CAS No.	2112737-93-4
Molecular Formula	C85H164N2O23P
Molecular Weight	~1620.2 g/mol
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (propargyl); DSPE-PEG5-Alkyne; DSPE-PEG(2000)-Propargyl; 1,2-Dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]-prop-2-yn-1-amine; Propargyl-PEG5-DSPE; Lipid-PEG-Alkyne; Phosphoethanolamine-PEG-Propargyl
EINECS	Contact for details

Quality Control

Our Dspe-Peg5-Propargyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing purity, functional group integrity, and critical impurities are provided to ensure the material meets the stringent requirements for pharmaceutical R&D and GMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize condensation and hydrolysis. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Integrity	≥ 90% (Propargyl group)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.