Description

Dspe-Peg5-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a distearoylphosphatidylethanolamine (DSPE) lipid tail and a terminal azide group. This compound is engineered for the controlled conjugation and functionalization of biomolecules, enabling precise nanoscale assembly. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science who require reliable, high-purity linkers for creating targeted drug delivery systems and diagnostic tools.

Application

• Lipid Nanoparticle (LNP) Formulation: As a functionalizable PEG-lipid conjugate for modulating the surface properties and stability of mRNA or siRNA delivery vehicles.
• Click Chemistry Bioconjugation: Utilizes the azide group for copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) to attach targeting ligands, dyes, or drugs to lipid membranes.
• Liposome Surface Engineering: For introducing stealth properties (PEGylation) and creating "clickable" sites on liposomal surfaces for subsequent modular attachment.
• Prodrug Synthesis: Serves as a linker in the synthesis of lipid-drug conjugates, facilitating the creation of stimuli-responsive or targeted prodrugs.
• Biomaterial Functionalization: Used to modify surfaces of biomaterials with bioactive lipid layers to control cell-material interactions.
• Diagnostic Probe Assembly: Enables the construction of multimodal imaging probes by conjugating contrast agents to lipid-based carriers.

Basic Information

Product Name	Dspe-Peg5-Azide
CAS No.	2112737-73-0
Molecular Formula	C73H141N4O18P
Molecular Weight	1386.9 g/mol
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000]; DSPE-PEG(2000)-Azide; DSPE-PEG2k-N3; 1,2-Dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]-azide; Azido-PEG2000-DSPE; DSPE-PEG-Azide (MW 2000); Phospholipid-PEG-Azide
EINECS	Contact for details

Quality Control

Every batch of Dspe-Peg5-Azide is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with cGMP guidelines for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity, functional group integrity, and critical impurities. Our quality commitment guarantees batch-to-batch consistency for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize condensation and hydrolysis. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (H-NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Functional Group (Azide)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.