Description

n-(Aminooxy-Peg2)-n-Bis(Peg3-Propargyl) CAS NO 2112737-71-8 is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group and two propargyl groups. This compound is engineered for precision bioconjugation, enabling the stable, site-specific crosslinking of biomolecules such as proteins, peptides, and oligonucleotides. It is a critical reagent for researchers and manufacturers in the fields of biopharmaceutical development, advanced diagnostics, and materials science.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of payloads to antibodies for the production of Antibody-Drug Conjugates (ADCs).
• PEGylation: Modification of therapeutic proteins and peptides to enhance solubility, stability, and circulation half-life.
• Surface Functionalization: Immobilization of biomolecules onto solid supports (e.g., biosensors, microarrays, nanoparticles) via click chemistry.
• Crosslinking Agent: Creation of hydrogels and polymer networks for tissue engineering and drug delivery systems.
• Diagnostic Probe Synthesis: Construction of labeled probes for imaging and detection assays.
• Chemical Biology Tool: Facilitating the study of biomolecular interactions and cellular processes through designed crosslinking.

Basic Information

Product Name	n-(Aminooxy-Peg2)-n-Bis(Peg3-Propargyl)
CAS No.	2112737-71-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl); Aminooxy-PEG2-bis(PEG3-propargyl); Heterobifunctional PEG linker, Aminooxy/Propargyl; O-(2-Aminoethoxy)ethyl-N,N-bis[2-[2-(2-prop-2-yn-1-yloxyethoxy)ethoxy]ethoxy]ethyl]hydroxylamine; Propargyl-PEG3-Aminooxy-PEG2; Bifunctional PEG crosslinker; Click chemistry linker; Oxylamine-PEG2-bis(Propargyl-PEG3)
EINECS	Contact for details

Quality Control

Our n-(Aminooxy-Peg2)-n-Bis(Peg3-Propargyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially oxidizable nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Integrity	≥ 90% (by NMR titration)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.