Description

n-(Propargyl-Peg4-Carbonyl)-n-Bis(Peg1-Methyl Ester) is a specialized heterobifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and crosslinking applications. Its molecular architecture, featuring a propargyl group and methyl ester termini, provides orthogonal reactivity for click chemistry and subsequent functionalization, enabling precise and stable linkages in complex molecular assemblies. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require high-purity, functionalized linkers for creating next-generation biotherapeutics, diagnostic probes, and smart biomaterials.

Application

• Bioconjugation and Linker Chemistry: Serves as a key intermediate for attaching biomolecules (peptides, proteins, oligonucleotides) to surfaces, nanoparticles, or other polymers via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• ADC (Antibody-Drug Conjugate) Development: Used in the synthesis of PEGylated linkers to connect cytotoxic payloads to monoclonal antibodies, improving solubility, stability, and pharmacokinetic profiles.
• Proteomics and Biomarker Research: Facilitates the labeling and enrichment of target proteins or peptides for mass spectrometry analysis and activity-based protein profiling.
• Polymer and Hydrogel Synthesis: Acts as a functional crosslinker or monomer for creating PEG-based hydrogels with tailored degradation rates and mechanical properties for drug delivery and tissue engineering.
• Diagnostic Reagent Formulation: Employed in the development of contrast agents, fluorescent probes, and assay components where water solubility and specific bio-recognition are critical.
• Surface Functionalization: Used to modify gold nanoparticles, quantum dots, or sensor chips with bio-compatible PEG spacers, reducing non-specific binding and enabling oriented immobilization.

Basic Information

Item	Details
Product Name	n-(Propargyl-Peg4-Carbonyl)-n-Bis(Peg1-Methyl Ester)
CAS No.	2112732-01-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Propargyl-PEG4-acid, Bis(Methyl Ester); 2,5,8,11-Tetraoxatetradeca-13-yn-14-oic acid, 14-oxo-, 1,1'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)] ester; Propargyl-PEG4-C2-acid, Bis-Methyl Ester; Heterobifunctional PEG Alkyne Ester; Alkyne-PEG4-tetracarboxylic acid, Dimethyl Ester; N-(Prop-2-yn-1-yl)-3,6,9,12-tetraoxapentadecanedioic acid dimethyl ester; Propargyl-O1-(2-Carboxyethyl)-O4-(2-methoxy-2-oxoethyl)-3,6,9,12-tetraoxapentadecanedioate
EINECS	Contact for details

Quality Control

Our n-(Propargyl-Peg4-Carbonyl)-n-Bis(Peg1-Methyl Ester) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the exacting standards required for research and commercial-scale bioconjugation. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for critical pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic (moisture-sensitive) nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.