Description

Estriol (2,4,16,17-D4, 98%) 95% Cp is a high-purity, deuterium-labeled analog of the endogenous estrogen hormone estriol. This compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reproducibility in complex biological matrices. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and analytical testing facilities engaged in hormone analysis, pharmacokinetic studies, and metabolomics research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of endogenous estriol in bioanalytical methods, including serum, plasma, and urine analysis.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies for hormone-based therapeutics.
• Clinical Diagnostics: Supports the development and validation of high-sensitivity assays for monitoring hormonal status in pregnancy and endocrine disorders.
• Metabolomics and Biomarker Discovery: Enables accurate profiling of estrogen metabolites in research studies investigating endocrine-related diseases.
• Quality Control & Method Validation: Serves as a certified reference material (CRM) for calibrating instruments and validating analytical procedures in GLP/GMP environments.

Basic Information

Product Name	Estriol (2,4,16,17-D4, 98%) 95% Cp
CAS No.	2111805-38-8
Molecular Formula	C18H20D4O3
Molecular Weight	288.40 g/mol
Synonyms	Estriol-d4; 1,3,5(10)-Estratrien-3,16α,17β-triol-2,4,16,17-d4; 16α-Hydroxyestradiol-d4; Oestriol-d4; E3-d4; Deuterated Estriol; [2,4,16,17-D4]-Estriol
EINECS	Contact for details

Quality Control

Every batch of our deuterated estriol is produced and analyzed under strict quality management protocols. The product is characterized to confirm isotopic enrichment (98% D) and chemical purity (95% Cp) using advanced techniques including NMR and HPLC. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, isotopic purity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.