Description

n-Mal-n-Bis(Peg2-Acid) CAS NO 2110449-02-8 is a specialized bifunctional PEG derivative featuring maleimide and carboxylic acid termini, designed for advanced bioconjugation and linker chemistry. This compound is engineered to enable the precise, site-specific crosslinking of biomolecules, offering controlled reactivity and enhanced aqueous solubility. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay production, where reliable and efficient conjugation strategies are critical.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a heterobifunctional crosslinker for connecting cytotoxic payloads to monoclonal antibodies via thiol-maleimide chemistry.
• Protein and Peptide Modification: Enables site-specific labeling, PEGylation, or immobilization of proteins through reaction with cysteine residues.
• Surface Functionalization: Used to modify nanoparticles, biosensors, or chromatographic media with carboxylic acid groups for further coupling via EDC/NHS chemistry.
• Diagnostic Reagent Synthesis: A key intermediate in constructing fluorescent or enzyme-labeled probes for immunoassays and molecular imaging.
• Polymer and Hydrogel Synthesis: Acts as a functional monomer or crosslinking agent in the development of biocompatible and stimuli-responsive materials.
• Biomaterial Engineering: Facilitates the creation of bioactive scaffolds for tissue engineering by conjugating signaling peptides or growth factors.

Basic Information

Product Name	n-Mal-n-Bis(Peg2-Acid)
CAS No.	2110449-02-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG2-acid; 3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid; 1-(8-Carboxy-3,6-dioxaoctyl)maleimide; Bifunctional PEG linker, Maleimide-PEG2-COOH; Heterobifunctional PEG crosslinker; NHS-PEG2-Maleimide precursor; mPEG2-acid, Maleimide terminated
EINECS	Contact for details

Quality Control

Our n-Mal-n-Bis(Peg2-Acid) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, Acetonitrile, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.