Description

2,5-Dioxopyrrolidin-1-Yl 3-(2-(2-(1,3-Dioxoisoindolin-2-Yloxy)Ethoxy)Ethoxy)Propanoate is a specialized heterobifunctional crosslinking reagent designed for advanced bioconjugation and polymer chemistry. This compound matters for its ability to introduce stable, cleavable linkages between biomolecules or synthetic polymers, enabling precise control over molecular assembly. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and advanced material science.

Application

• Bioconjugation Reagent: For the site-specific crosslinking of proteins, peptides, and antibodies with other biomolecules or solid supports.
• Proteomics Research: Used in the preparation of affinity probes and activity-based protein profiling (ABPP) to study enzyme function and interactions.
• Polymer Functionalization: Acts as a key monomer or end-capping agent for synthesizing stimuli-responsive and biodegradable polymers.
• Drug Delivery Systems: Facilitates the creation of linker-drug conjugates in antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Surface Immobilization: Enables the covalent attachment of bioactive molecules to chips, beads, and nanoparticles for biosensor and diagnostic assay development.
• Material Crosslinking: Used in the development of hydrogels and other polymeric networks with tailored degradation profiles.

Basic Information

Product Name	2,5-Dioxopyrrolidin-1-Yl 3-(2-(2-(1,3-Dioxoisoindolin-2-Yloxy)Ethoxy)Ethoxy)Propanoate
CAS No.	2101206-31-7
Molecular Formula	C21H24N2O10
Molecular Weight	464.42 g/mol
Synonyms	NHS-PEG2-Phth; N-Hydroxysuccinimide ester of Phth-PEG2-acid; 3-(2-(2-(1,3-Dioxoisoindolin-2-yloxy)ethoxy)ethoxy)propanoic acid N-succinimidyl ester; Phthalimide-PEG2-NHS ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(1,3-dioxoisoindol-2-yl)oxyethoxy]ethoxy]propanoate; SG-PEG2-NHS; Phth-PEG2-NHS Ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity and high purity suitable for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.