Description

n-Mal-n-Bis(Peg4-Acid) CAS NO 2100306-52-1 is a specialized, high-purity bifunctional PEG derivative featuring a maleimide group and two terminal carboxylic acids, connected by tetraethylene glycol (PEG4) spacers. This molecular architecture is critical for creating stable, site-specific bioconjugates and functionalized materials with controlled spacing and aqueous solubility. It is an essential building block for researchers and manufacturers in advanced life sciences and nanotechnology who require precise, reproducible cross-linking and surface modification. The compound enables the development of targeted drug delivery systems, diagnostic assays, and biocompatible hydrogels.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, or peptides via the maleimide-thiol chemistry, with the carboxylic acid termini allowing for further labeling or attachment to solid supports.
• Functionalized Nanoparticle Synthesis: Surface modification of quantum dots, liposomes, or polymeric nanoparticles to introduce reactive carboxyl groups for subsequent biomolecule immobilization.
• Hydrogel and Biomaterial Fabrication: Serving as a cross-linker or functional monomer in the synthesis of PEG-based hydrogels for tissue engineering and controlled release applications.
• Diagnostic Reagent Preparation: Conjugation of enzymes, fluorescent dyes, or haptens to carrier proteins for use in ELISA, lateral flow assays, and other immunoassays.
• Affinity Chromatography Ligand Coupling: Immobilization of proteins, peptides, or other ligands onto carboxyl-functionalized resins or magnetic beads.
• Polymer Chemistry: Use as a macromonomer or chain extender in the synthesis of functional, water-soluble copolymers.

Basic Information

Product Name	n-Mal-n-Bis(Peg4-Acid)
CAS No.	2100306-52-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG4-acid; Bis-Carboxy-PEG4-maleimide; 1,11-Bis(carboxymethyl)-3,9-dioxa-6-aza-1,11-undecanedione maleimide derivative; α-Maleimido-ω-carboxy PEG4 acid; Maleimide-PEG4-bis(acetic acid); PEG4-based maleimide carboxylic acid crosslinker; 2,2'-(2,2'-(2-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethyl)azanediyl)diacetic acid (related structure); MAL-PEG4-COOH
EINECS	Contact for details

Quality Control

Our n-Mal-n-Bis(Peg4-Acid) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.