Description

E3 Ligand-Linker Conjugate 4 is a sophisticated bifunctional chemical entity designed for targeted protein degradation applications. This compound is critical for researchers and developers in the field of proteolysis-targeting chimeras (PROTACs), enabling the precise hijacking of cellular degradation machinery. It is primarily utilized by pharmaceutical R&D teams and biotechnology companies focused on novel therapeutic modalities for oncology, neurodegenerative diseases, and other challenging targets.

Application

• PROTAC Molecule Synthesis: Serves as a key building block for constructing heterobifunctional degraders that link an E3 ubiquitin ligase ligand to a target protein-binding warhead.
• Chemical Biology Research: Used in academic and industrial labs to study ubiquitin-proteasome system (UPS) pathways and validate novel E3 ligases for drug discovery.
• Preclinical Drug Development: Enables the rapid prototyping and optimization of degrader candidates for improved potency, selectivity, and pharmacokinetic properties.
• Bioconjugation: The reactive linker moiety allows for conjugation to antibodies, peptides, or other targeting molecules to create complex targeted degradation tools.
• Library Synthesis: Employed in the generation of focused screening libraries to explore structure-activity relationships (SAR) for novel E3 ligase engagements.

Basic Information

Product Name	E3 Ligand-Linker Conjugate 4
CAS No.	2093388-45-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 4; E3 Ligand-Linker 4; Targeted Protein Degradation Conjugate 4; Bifunctional Degrader Building Block 4; Ubiquitin Ligase Recruitment Molecule 4; Heterobifunctional Molecule 2093388-45-3; Linker-E3 Ligand Conjugate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of E3 Ligand-Linker Conjugate 4 is characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to strict quality management protocols suitable for research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.