Description

n-(Amino-Peg4)-n-Bis(Peg4-T-Butyl Ester) is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine and two terminal tert-butyl ester-protected carboxylic acid groups. This compound is specifically engineered as a versatile linker and spacer molecule for advanced bioconjugation and materials science applications, enabling the controlled assembly of complex architectures. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise, water-soluble linkers for drug delivery systems, peptide synthesis, and surface functionalization. The CAS number for this compound is 2093153-97-8.

Application

• Bioconjugation & Drug Delivery: Serves as a key heterobifunctional crosslinker for attaching targeting ligands, drugs, or imaging agents to nanoparticles, antibodies, or proteins, facilitating the development of antibody-drug conjugates (ADCs) and other therapeutic constructs.
• Peptide & Protein Modification: Used to introduce PEG chains (PEGylation) to improve the solubility, stability, and pharmacokinetic profiles of peptides and therapeutic proteins.
• Polymer & Biomaterial Synthesis: Acts as a functional monomer or initiator for creating advanced, biocompatible hydrogels, dendrimers, and smart polymers with tailored degradation and release properties.
• Diagnostic Reagent Development: Employed in the synthesis of probes and labels for immunoassays, biosensors, and in-vivo imaging due to its ability to reduce non-specific binding and enhance signal-to-noise ratios.
• Surface Functionalization: Utilized to modify surfaces (e.g., gold, silica, polymers) with amine-reactive or acid-reactive groups for creating bioactive coatings, microarrays, and lab-on-a-chip devices.
• Click Chemistry & Orthogonal Labeling: The protected ester and amine functionalities allow for sequential, orthogonal chemical reactions, making it a valuable building block in multi-step synthetic strategies.

Basic Information

Product Name	n-(Amino-Peg4)-n-Bis(Peg4-T-Butyl Ester)
CAS No.	2093153-97-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid, 15-(1,1-dimethylethyl) ester, 15-[2-[2-[2-[2-[bis[2-[2-[2-[2-[(1,1-dimethylethoxy)carbonyl]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]amino]ethoxy]ethoxy]ethoxy]ethyl ester; Amino-PEG4-t-butyl ester-PEG4-t-butyl ester; Heterobifunctional PEG Amine, t-Butyl Ester; N-(Amino-PEG4)-N-bis(PEG4-acid t-butyl ester); 15-Amino-4,7,10,13-tetraoxapentadecanoic Acid 1,1-Dimethylethyl Ester, Polymer with Oxirane
EINECS	Contact for details

Quality Control

Our n-(Amino-Peg4)-n-Bis(Peg4-T-Butyl Ester) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at or below -20°C under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.