Description

Guanosine 5'-(Trihydrogen Diphosphate), 7-Methyl-3'-o-Methyl-, Inner Salt, Compd. With N,n-Diethylethanamine (1:) is a chemically modified nucleotide analog of significant interest in advanced biochemical research and pharmaceutical development. This compound matters for its role as a key intermediate or reference standard in the synthesis and study of novel RNA therapeutics, antiviral agents, and epigenetic modifiers. It is primarily needed by research institutions, biotechnology companies, and pharmaceutical manufacturers engaged in nucleoside chemistry, drug discovery, and the development of mRNA-based technologies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies, particularly those involving RNA cap analogs and methyltransferases.
• mRNA Technology Development: Acts as a key material in research focused on improving the stability, translation efficiency, and immunogenicity of synthetic mRNA for therapeutic and vaccine applications.
• Epigenetics Research: Employed in studies investigating RNA methylation and its role in gene expression regulation and cellular processes.
• Process Development & Scale-up: Utilized by process chemists for developing and optimizing scalable synthetic routes for advanced nucleotide analogs.
• Analytical Standard: Provides a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	Guanosine 5'-(Trihydrogen Diphosphate), 7-Methyl-3'-o-Methyl-, Inner Salt, Compd. With N,n-Diethylethanamine (1:)
CAS No.	2089461-52-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Methyl-3'-O-methylguanosine 5'-diphosphate triethylamine salt; 7-Methyl-3'-O-methyl-GDP triethylamine salt; N7-Methyl-3'-O-methylguanosine 5'-diphosphate TEA salt; 3'-O-Methyl-7-methylguanosine diphosphate triethylammonium salt; GDP analog, 7-methyl-3'-O-methyl-; Modified guanosine diphosphate; Cap analog intermediate; CAS 2089461-52-7
EINECS	Contact for details

Quality Control

Our Guanosine 5'-(Trihydrogen Diphosphate), 7-Methyl-3'-o-Methyl-, Inner Salt, Compd. With N,n-Diethylethanamine (1:) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥95.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Solvent Residues (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.