Description

T-Boc-n-Amido-Peg5-Propargyl CAS NO 2062663-67-4 is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (Boc)-protected amine at one terminus and a propargyl group at the other. This compound is a critical reagent in bioconjugation and click chemistry, enabling the precise, site-specific coupling of biomolecules, polymers, and small molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing targeted drug delivery systems, diagnostic probes, and functionalized hydrogels.

Application

• Bioconjugation Reagent: For the site-specific modification of peptides, proteins, and antibodies via amine-reactive chemistry and copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• ADC (Antibody-Drug Conjugate) Development: Serves as a functionalized PEG spacer to link cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• Polymer and Dendrimer Functionalization: Used to introduce clickable alkyne handles onto polymer backbones for subsequent modular assembly.
• Surface Modification: Enables the creation of biofunctional coatings on nanoparticles, biosensors, and microarray slides for enhanced biocompatibility and targeting.
• Proteomics Research: Acts as a crosslinker or affinity tag in chemical proteomics for studying protein-protein interactions and post-translational modifications.
• Hydrogel Synthesis: Incorporated as a crosslinking agent to create PEG-based hydrogels with tailored mechanical properties and bioactivity for tissue engineering.
• Fluorescent Probe Synthesis: Facilitates the attachment of fluorophores to biomolecules for imaging and diagnostic applications.
• Small Molecule Library Synthesis: Provides a versatile building block for combinatorial chemistry and the synthesis of compound libraries via click chemistry.

Basic Information

Product Name	T-Boc-n-Amido-Peg5-Propargyl
CAS No.	2062663-67-4
Molecular Formula	C27H51NO10
Molecular Weight	549.7 g/mol
Synonyms	1-Boc-1,2-diamino-3,6,9,12,15-pentaoxaoctadec-17-yn-18-ol; 2,5,8,11,14-Pentaoxa-17-azanonadec-18-yn-1-oic acid, 17-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester; Boc-NH-PEG5-propargyl; tert-Butyl (17-(prop-2-yn-1-yl)-2,5,8,11,14-pentaoxa-17-azanonadecan-19-yl)carbamate; Boc-Amine-PEG5-Alkyne; N-Boc-1,2-diamino-PEG5-propargyl; Boc-protected Amino-PEG5-Propargyl; Alkyne-PEG5-Boc-amine
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg5-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and development documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.