Description

T-Boc-Aminooxy-Peg3-Oxyamine is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butoxycarbonyl (T-Boc) protected aminooxy group and an oxyamine terminus. This compound is specifically engineered for the controlled conjugation and bioconjugation of biomolecules, offering orthogonal reactivity for advanced chemical biology applications. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and materials science, enabling the creation of stable, site-specific linkages for drug delivery systems, diagnostic assays, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, or peptides with cytotoxic drugs, fluorophores, or other payloads for antibody-drug conjugates (ADCs) and diagnostic tools.
• PEGylation Chemistry: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic peptides and small molecules.
• Surface Functionalization: Modification of nanoparticles, biosensors, and microarray surfaces to create reactive platforms for biomolecule immobilization.
• Crosslinking Agent: Used as a heterobifunctional crosslinker to bridge carbonyl-containing molecules (via the aminooxy group) with other amine-reactive entities.
• Chemical Biology Probes: Synthesis of activity-based probes and affinity labels for studying protein function and interactions.
• Polymer and Biomaterial Synthesis: Building block for creating functionalized hydrogels, smart polymers, and drug-eluting materials with tailored release profiles.

Basic Information

Product Name	T-Boc-Aminooxy-Peg3-Oxyamine
CAS No.	2062663-66-3
Molecular Formula	C16H32N2O8
Molecular Weight	380.44 g/mol
Synonyms	1-Amino-11-((tert-butoxycarbonyl)amino)-3,6,9-trioxaundecan-11-one O-methyloxime; Boc-NH-PEG3-ONH2; tert-Butyl (13-(methoxyamino)-13-oxo-3,6,9-trioxa-12-azatridecyl)carbamate; Aminooxy-PEG3-t-butyloxycarbonyl; T-Boc-aminoxy-PEG3-oxyamine; Boc-Aminooxy-PEG3-oxyamine; (1-(tert-Butoxy)-1-oxo-3,6,9,12-tetraoxa-2-azapentadecan-15-oic acid, 2-methyl-2-propanyl ester
EINECS	Contact for details

Quality Control

Every batch of T-Boc-Aminooxy-Peg3-Oxyamine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key specifications such as assay, impurity profile, and moisture content. Our quality commitment supports applications in GMP-compliant research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, dichloromethane, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.