Description

Me-Tet-Peg4-Nh2 CAS NO 2055646-21-2 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a methyltetrazine group and a primary amine, connected by a tetraethylene glycol spacer. This compound is a critical building block in bioconjugation and click chemistry, enabling the stable, site-specific labeling of biomolecules for research and therapeutic development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors who require high-purity, functional linkers for advanced drug delivery systems, antibody-drug conjugates (ADCs), and bioimaging probes.

Application

• Bioconjugation and Click Chemistry: Serves as a key reagent for bioorthogonal labeling via the inverse electron demand Diels-Alder (IEDDA) reaction between the methyltetrazine and trans-cyclooctene (TCO) groups.
• Antibody-Drug Conjugate (ADC) Development: Used as a functional linker to connect cytotoxic payloads to monoclonal antibodies, enhancing solubility and pharmacokinetics.
• PEGylation of Biomolecules: The amine terminus allows for conjugation to carboxyl groups or other activated sites on peptides, proteins, and oligonucleotides, while the PEG spacer improves solubility and reduces immunogenicity.
• Diagnostic Probe Synthesis: Facilitates the creation of targeted imaging agents for fluorescence, PET, or SPECT imaging by linking targeting vectors to reporter molecules.
• Surface Functionalization: Employed to modify nanoparticles, microspheres, or biosensor surfaces with amine-reactive chemistry for subsequent biomolecule immobilization.
• Prodrug Synthesis: Enables the design of cleavable prodrug linkers that release active pharmaceutical ingredients (APIs) under specific physiological conditions.

Basic Information

Product Name	Me-Tet-Peg4-Nh2
CAS No.	2055646-21-2
Molecular Formula	C24H40N6O7
Molecular Weight	524.61 g/mol
Synonyms	Methyltetrazine-PEG4-amine; 5-Methyl-1,2,4,5-tetrazin-3-amine, 6-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]-; Me-Tetrazine-PEG4-NH2; Methyl-Tet-PEG4-Amine; 6-(17-Amino-3,6,9,12-tetraoxaheptadec-1-yl)-5-methyl-1,2,4,5-tetrazin-3-amine; TZ-PEG4-NH2; Amine-PEG4-Methyltetrazine; Heterobifunctional PEG linker Me-Tet-PEG4-NH2
EINECS	Contact for details

Quality Control

Our Me-Tet-Peg4-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store the product at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange viscous oil or solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.