Description

Sulfo Dbco-Peg4-Maleimide CAS NO 2055198-07-5 is a heterobifunctional crosslinker featuring a water-soluble sulfonate group, a polyethylene glycol (PEG) spacer, and two highly selective reactive handles: a DBCO group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a maleimide group for thiol conjugation. This dual functionality is critical for creating stable, site-specific bioconjugates under mild, aqueous conditions without the need for metal catalysts. It is an essential reagent for researchers and developers in bioconjugation, ADC (Antibody-Drug Conjugate) development, and advanced biomaterial fabrication.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the precise, stable attachment of cytotoxic payloads to monoclonal antibodies via thiol-maleimide and SPAAC chemistries.
• PEGylated Bioconjugate Synthesis: To introduce hydrophilic PEG spacers between biomolecules (e.g., proteins, peptides) and labels (e.g., dyes, drugs) to improve solubility and pharmacokinetics.
• Surface Functionalization: For modifying nanoparticles, biosensors, or microarray slides with biomolecular probes in a controlled, oriented manner.
• Click Chemistry-Based Labeling: Enables efficient, bioorthogonal labeling of azide-modified biomolecules (e.g., glycans, metabolically engineered cells) with thiol-containing probes.
• Hydrogel and Biomaterial Crosslinking: Serves as a crosslinking agent for creating smart, responsive hydrogels for drug delivery and tissue engineering applications.
• Diagnostic Reagent Development: Used in the construction of immunoassay components, such as enzyme-antibody conjugates, requiring stable, defined linkages.

Basic Information

Item	Detail
Product Name	Sulfo Dbco-Peg4-Maleimide
CAS No.	2055198-07-5
Molecular Formula	C33H43N3O13S
Molecular Weight	721.78 g/mol
Synonyms	Sulfo-DBCO-PEG4-Maleimide; DBCO-Sulfo-PEG4-MAL; DBCO-PEG4-Sulfo-Maleimide; Dibenzocyclooctyne-PEG4-Sulfonate-Maleimide; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-{2-[2-(2-{3-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methoxy]-3-oxopropoxy}ethoxy)ethoxy]ethoxy}ethyl) Carbonimidothioate, 1-Oxide; Sulfo-DBCO-PEG4-MAL; Water-Soluble DBCO-PEG4-Maleimide
EINECS	Contact for details

Quality Control

Our Sulfo Dbco-Peg4-Maleimide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, strength, and composition. A detailed Certificate of Analysis (COA) documenting these results is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.