Description

Ald-Ph-Peg12-Tfp Ester is a specialized bifunctional polyethylene glycol (PEG) derivative featuring an aldehyde group and a tetrafluorophenyl (TFP) ester reactive handle. This compound is engineered for high-value bioconjugation and crosslinking applications, offering controlled reactivity and aqueous solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors for creating stable protein-polymer conjugates, modifying surfaces, and synthesizing complex biomaterials.

Application

• Bioconjugation Linker: For site-specific modification of proteins, antibodies, and peptides via amine-reactive TFP ester and subsequent aldehyde-mediated coupling.
• PEGylation Reagent: Used in the development of PEGylated therapeutic proteins to enhance pharmacokinetic properties such as solubility and circulation half-life.
• Hydrogel Formation: Serves as a crosslinker in the synthesis of biocompatible hydrogels for drug delivery systems and tissue engineering scaffolds.
• Surface Functionalization: Enables the covalent attachment of biomolecules to sensor surfaces, nanoparticles, and other material interfaces for diagnostic and research applications.
• Antibody-Drug Conjugate (ADC) Synthesis: A key intermediate in constructing linker-payload systems for targeted cancer therapies.
• Diagnostic Probe Development: Facilitates the labeling of detection molecules (e.g., enzymes, fluorophores) in immunoassay and biosensor platforms.

Basic Information

Product Name	Ald-Ph-Peg12-Tfp Ester
CAS No.	2055105-36-5
Molecular Formula	C58H84F4O17
Molecular Weight	1129.3 g/mol
Synonyms	4-Formylbenzyl-PEG12-TFP ester; Aldehyde-PEG12-Tetrafluorophenyl ester; Fmoc-PEG12-CHO TFP ester (precursor); α-Aldehyde-ω-tetrafluorophenyl ester PEG12; Benzaldehyde-PEG12-TFP Ester; 12-Amino-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxanonatriacontan-39-oic acid, 2,3,5,6-tetrafluorophenyl ester; Poly(ethylene glycol) derivative, aldehyde and TFP terminated.
EINECS	Contact for details

Quality Control

Our Ald-Ph-Peg12-Tfp Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation by NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade material standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the active ester. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Aldehyde)	≥ 90% of theoretical
Functional Group Assay (TFP Ester)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.