Description

Azido-Peg5-Ala-Ala-Asn-Pab is a specialized peptide-PEG conjugate featuring an azide functional group for bioorthogonal click chemistry applications. This compound is engineered to serve as a versatile linker or spacer, enabling the site-specific modification of biomolecules, surfaces, or nanoparticles. It is primarily utilized by researchers and developers in the fields of bioconjugation, pharmaceutical development, and advanced materials science to create targeted drug delivery systems, diagnostic probes, and functional biomaterials.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Acts as a cleavable linker for attaching cytotoxic payloads to targeting antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Protease-Activated Prodrugs: The Ala-Ala-Asn sequence is a substrate for specific proteases (e.g., legumain), allowing for the design of tumor microenvironment-responsive drug release systems.
• Surface Functionalization: Used to modify nanoparticles, chips, or beads with azide groups for subsequent click chemistry-based immobilization of ligands, proteins, or dyes.
• Chemical Biology Tool Development: Serves as a key reagent for labeling and tracking biomolecules in live cells or complex biological samples.
• Polymer and Biomaterial Science: Incorporated into hydrogels or polymeric scaffolds to introduce bioresponsive degradation or cell-adhesive motifs.
• Diagnostic Assay Development: Facilitates the construction of sensitive immunoassays or biosensors through controlled biomolecule attachment.

Basic Information

Item	Detail
Product Name	Azido-Peg5-Ala-Ala-Asn-Pab
CAS No.	2055048-54-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Azido-PEG5-AAN-PAB; N3-PEG5-Ala-Ala-Asn-PAB; Azido-Pentaglycol-Ala-Ala-Asn-P-Aminobenzyloxycarbonyl; AAN-PAB(N3-PEG5); Legumain Substrate Azido-PEG Conjugate; Azido-PEG5-AAN-PABC; Protease Cleavable Azide Linker; 5-Azido-3,6,9,12,15-pentaoxa-2-azaheptadecan-1-oic acid-(L-Ala)-(L-Ala)-(L-Asn)-p-aminobenzyloxycarbonyl
EINECS	Contact for details

Quality Control

Our Azido-Peg5-Ala-Ala-Asn-Pab is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and NMR analyses. We support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.