Description

Propargyl-Peg4-S-Peg4-Propargyl CAS NO 2055041-17-1 is a heterobifunctional polyethylene glycol (PEG) linker featuring terminal propargyl groups and a central disulfide bond. This compound is engineered to enable controlled conjugation and release strategies in advanced bioconjugation and materials science. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and nanotechnology, where precise, stimuli-responsive crosslinking is required.

Application

• ADC (Antibody-Drug Conjugate) Linker: Serves as a cleavable linker for constructing ADCs, utilizing the reducible disulfide bond for targeted drug release in tumor microenvironments.
• Bioconjugation & Protein Modification: Facilitates site-specific labeling of proteins, peptides, and antibodies via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Polymer & Hydrogel Synthesis: Acts as a crosslinking agent for creating smart, stimuli-responsive hydrogels and polymeric networks for drug delivery and tissue engineering.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and diagnostic assay surfaces with functional alkyne groups for subsequent biomolecule attachment.
• Prodrug Design: Enables the development of prodrugs where the active pharmaceutical ingredient is released upon reduction of the disulfide linkage.
• Chemical Biology Probes: A key building block for synthesizing probes to study protein interactions, trafficking, and function in live cells.

Basic Information

Item	Detail
Product Name	Propargyl-Peg4-S-Peg4-Propargyl
CAS No.	2055041-17-1
Molecular Formula	C28H50N2O10S2
Molecular Weight	638.8 g/mol
Synonyms	1,11-Bis(prop-2-yn-1-yloxy)-3,6,9-trioxa-12-thia-2,10-diazatetradecane 13,13-dioxide; Propargyl-PEG4-SS-PEG4-propargyl; Bis(propargyl-PEG4) disulfide; Alkyne-PEG4-SS-PEG4-alkyne; Heterobifunctional PEG disulfide linker; SS-PEG4-(Propargyl)2; 2,2'-(Disulfanediylbis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(N-(prop-2-yn-1-yl)acetamide)
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-S-Peg4-Propargyl is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and moisture absorption. Allow the product to equilibrate to room temperature in a desiccator before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.