Description

T-Boc-Aminooxy-Peg3-S-Ac is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (T-Boc) protected aminooxy group and a thioacetate (S-Ac) terminus. This compound is a critical reagent for the site-specific conjugation of biomolecules, enabling the formation of stable oxime bonds with carbonyl groups under mild conditions. It is primarily utilized by researchers and process development scientists in the pharmaceutical and bioconjugation sectors for constructing antibody-drug conjugates (ADCs), peptide/protein modifications, and advanced drug delivery systems.

Application

• Key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Site-specific bioconjugation of peptides, proteins, and antibodies via oxime ligation.
• Functionalization of nanoparticles and liposomes for drug delivery system development.
• Crosslinking agent for surface modification and biomaterial engineering.
• Introduction of hydrophilic PEG spacers to improve solubility and pharmacokinetic properties of drug candidates.
• Tool compound for chemical biology research involving post-translational modifications.
• Preparation of diagnostic probes and imaging agents.

Basic Information

Product Name	T-Boc-Aminooxy-Peg3-S-Ac
CAS No.	2055040-71-4
Molecular Formula	C19H37N3O8S
Molecular Weight	467.58 g/mol
Synonyms	1-Aminooxy-2,5,8,11-tetraoxatridecan-13-yl thioacetate, tert-butyl carbamate; tert-Butyl N-(13-(acetylthio)-2,5,8,11-tetraoxatridec-1-yl)oxycarbamate; T-Boc-NH-O-PEG3-S-Ac; Boc-Aminooxy-PEG3-Thioacetate; Aminooxy-PEG3-Thioacetate t-butyl ester; Heterobifunctional PEG linker, Boc-protected; 2,5,8,11-Tetraoxatridecan-13-yl thioacetate, 1-[[(1,1-dimethylethoxy)carbonyl]amino]oxy]-
EINECS	Contact for details

Quality Control

Our T-Boc-Aminooxy-Peg3-S-Ac is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.