Description

Azido-Peg3-Sulfone-Peg4-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a carboxylic acid, connected by a sulfone-containing triethylene glycol and tetraethylene glycol spacer. This compound is engineered for high-efficiency bioconjugation, enabling stable and site-specific crosslinking in aqueous environments. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science, facilitating the creation of antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component for connecting cytotoxic payloads to monoclonal antibodies via click chemistry and amide bond formation.
• Protein and Peptide PEGylation: Used to modify therapeutic proteins to enhance solubility, stability, and circulation half-life while reducing immunogenicity.
• Surface Functionalization: Enables the covalent attachment of biomolecules (e.g., peptides, oligonucleotides) to nanoparticles, biosensors, and diagnostic arrays.
• Crosslinking Reagent: Facilitates the formation of stable bridges between molecules containing alkyne and amine groups for structural studies and material synthesis.
• Polymer Chemistry: Acts as a functional monomer or chain extender in the synthesis of advanced, stimuli-responsive polymeric materials.
• Diagnostic Probe Synthesis: Utilized in the development of fluorescent or radioactive probes for targeted imaging and detection.

Basic Information

Item	Details
Product Name	Azido-Peg3-Sulfone-Peg4-Acid
CAS No.	2055024-42-3
Molecular Formula	C21H39N3O12S
Molecular Weight	557.6 g/mol
Synonyms	Azido-PEG3-sulfone-PEG4-acid; 3-Azidopropyl-PEG3-sulfone-PEG4-acid; N3-PEG3-Sulfone-PEG4-COOH; 17-Azido-3,6,9,12,15-pentaoxa-18-thiaheptacosanoic acid 18,18-dioxide; Azido-PEG3-Sulfone-PEG4-Propionic Acid; PEG Azide Sulfone Acid; Heterobifunctional PEG Linker, Azide and Acid; Click Chemistry PEG Linker
EINECS	Contact for details

Quality Control

Every batch of Azido-Peg3-Sulfone-Peg4-Acid is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and functional integrity. Our quality protocols are designed to meet the stringent requirements for research-grade and cGMP starting material applications, ensuring batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical
Functional Group Assay (Acid)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.