Description

Acid-PEG4-S-S-PEG4-Acid is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring terminal carboxylic acid groups and a central disulfide bond. This molecular architecture is critical for creating cleavable, stimuli-responsive bioconjugates and drug delivery systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications requiring controlled release or reversible linkage.

Application

• Bioconjugation and Protein Modification: Used to link peptides, proteins, or antibodies to other molecules (e.g., drugs, surfaces, fluorophores) via its carboxylic acid termini, with the disulfide bond allowing reduction-triggered release.
• Stimuli-Responsive Drug Delivery Systems: Serves as a key component in the synthesis of nanocarriers (e.g., micelles, liposomes, polymer-drug conjugates) where the disulfide bridge cleaves in the reductive intracellular environment, enabling targeted payload release.
• Surface Functionalization and Hydrogel Formation: Facilitates the creation of smart surfaces or crosslinked hydrogel networks where material properties or cell interactions can be modulated by reducing agents.
• Linker for ADC (Antibody-Drug Conjugate) Development: Acts as a cleavable linker candidate in the design of ADCs, connecting cytotoxic drugs to monoclonal antibodies for selective cancer therapy.
• Crosslinking Agent for Nanomaterials: Employed to stabilize or functionalize nanoparticles (gold, iron oxide, etc.) with a cleavable PEG shell, enhancing biocompatibility and enabling triggered aggregation or drug release.
• Prodrug Synthesis: Used to create prodrugs where an active pharmaceutical ingredient is temporarily masked or conjugated via the acid and disulfide functionalities, becoming active upon specific biological reduction.

Basic Information

Product Name	Acid-PEG4-S-S-PEG4-Acid
CAS No.	2055015-40-0
Molecular Formula	C24H44N2O12S2 (or based on exact PEG unit count)
Molecular Weight	Contact for details
Synonyms	1,11-Bis(2,5-dioxopyrrolidin-1-yl)-3,6,9-trioxa-2,10-dithiadodecanedioate (related active ester form); HOOC-PEG4-S-S-PEG4-COOH; Disulfide-bis(PEG4-propionic acid); α,ω-Bis(carboxy)-disulfide-PEG4; DSPE-PEG4-S-S-PEG4-COOH (phospholipid conjugate form); Carboxylic acid-PEG4-disulfide-PEG4-carboxylic acid; Cleavable PEG crosslinker, acid terminated; 3,6,9,12-Tetraoxatetradecanedioic acid, 14,14'-dithiobis- (systematic fragment)
EINECS	Contact for details

Quality Control

Our Acid-PEG4-S-S-PEG4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) due to its hygroscopic nature. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to preserve the integrity of the disulfide bond. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Disulfide Bond Integrity (Assay)	≥ 90%
Solubility	Soluble in DMSO, DMF, water (partially)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.