Description

Acid-Peg3-Ss-Peg3-Acid CAS NO 2055014-98-5 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring terminal carboxylic acid groups and a central disulfide bond. This compound is engineered to enable controlled conjugation and release strategies in advanced bioconjugation and materials science. It is a critical reagent for researchers and manufacturers developing next-generation therapeutics and diagnostic platforms. The primary demand comes from the pharmaceutical, biotechnology, and life sciences sectors for applications in drug delivery, surface functionalization, and hydrogel formation.

Application

• Bioconjugation and Linker Chemistry: Used to covalently attach biomolecules (e.g., peptides, proteins, antibodies) via amine coupling, with the disulfide bond allowing for reductive cleavage under controlled conditions.
• Drug Delivery Systems: Serves as a cleavable linker in antibody-drug conjugates (ADCs) and nanoparticle-based delivery vehicles to facilitate targeted payload release.
• Surface Modification and Functionalization: Enables the creation of reactive, PEGylated surfaces on chips, beads, or implants for biosensing and biocompatibility enhancement.
• Hydrogel and Biomaterial Fabrication: Acts as a crosslinking agent to form stimuli-responsive hydrogels that degrade upon exposure to reducing environments.
• Proteomics and Protein Research: Utilized for reversible protein modification, immobilization, or the study of protein-protein interactions.
• Diagnostic Reagent Development: Incorporated into assay components and diagnostic probes where a reversible linkage is required.

Basic Information

Product Name	Acid-Peg3-Ss-Peg3-Acid
CAS No.	2055014-98-5
Molecular Formula	C18H32O10S2
Molecular Weight	472.57 g/mol
Synonyms	1,11-Dioxo-3,6,9-trioxa-12-thia-2,10-diazatetradecan-14-oic acid, 13-[(2-Carboxyethyl)dithio]-; PEG3-SS-PEG3-diacid; HOOC-PEG3-SS-PEG3-COOH; Carboxy-PEG3-SS-PEG3-carboxylic acid; 3,6,9-Trioxa-12-thia-2,10-diazatetradecanedioic acid, 13-[(2-carboxyethyl)dithio]-; Disulfide-bis(propanoic acid-PEG3); α,ω-Bis(carboxy-PEG3-propyl) disulfide; 2,2'-[Dithiobis[3-(2,5,8,11-tetraoxadodecan-12-yl)propanoic acid]]
EINECS	Contact for details

Quality Control

Our Acid-Peg3-Ss-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a dry, well-ventilated area. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere to preserve stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Titration)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.