Description

Desthiobiotin-Peg4-Dbco is a high-purity, multifunctional chemical linker designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and developers requiring precise, stable, and efficient coupling of biomolecules, such as proteins, peptides, and oligonucleotides. It is essential for professionals in pharmaceutical R&D, proteomics, diagnostic assay development, and materials science who are building next-generation targeted therapies, biosensors, and functionalized surfaces.

Application

• ADC (Antibody-Drug Conjugate) Development: Used as a key linker component to attach cytotoxic payloads to monoclonal antibodies via bioorthogonal click chemistry.
• Proteomics & Protein Labeling: Enables site-specific labeling and pull-down assays for protein interaction studies and biomarker discovery.
• Diagnostic Reagent Synthesis: Facilitates the creation of stable, high-affinity conjugates for ELISA, lateral flow assays, and other diagnostic platforms.
• Surface Functionalization: Used to modify nanoparticles, chips, and other materials with biotin or other targeting moieties for biosensing and cell capture.
• Chemical Biology Tool Development: Serves as a versatile building block for creating probes to study biological processes in live cells.
• Oligonucleotide Conjugation: Enables the attachment of tracking labels or functional groups to DNA/RNA strands for therapeutic and research applications.

Basic Information

Product Name	Desthiobiotin-Peg4-Dbco
CAS No.	2032788-37-5
Molecular Formula	C₃₈H₆₀N₆O₁₀S
Molecular Weight	780.99 g/mol
Synonyms	DBCO-PEG4-Desthiobiotin; Desthiobiotin-PEG4-DBCO; (1R,2S,3R,5S)-3-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-5-((3-(4-((1-(11-(3-((3aS,6S,6aR)-6-Methyl-2-oxotetrahydro-3aH-cyclopenta[d][1,3]dioxol-5-yl)propanoyl)piperazin-1-yl)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)butyl)amino)-3-oxopropyl)carbamoyl)cyclopentane-1,2-diyl diacetate; DBCO-PEG4-Desthiobiotin Conjugate; Azide-Free Biotinylation Reagent; Dibenzocyclooctyne-PEG4-Desthiobiotin
EINECS	Contact for details

Quality Control

Our Desthiobiotin-Peg4-Dbco is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for sensitive research and development applications. Certificates of Analysis (COA) with full analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.