Description

Maleimido-Mono-Amide-Dtpa is a heterobifunctional chelating agent designed for advanced bioconjugation and labeling applications. This compound matters for its ability to covalently link biomolecules via its maleimide group while simultaneously chelating metal ions, such as gadolinium or indium, through its DTPA-derived moiety. It is essential for researchers and manufacturers in the fields of diagnostic imaging, radiopharmaceuticals, and targeted drug delivery who require precise and stable labeling of proteins, antibodies, and peptides.

Application

• Radiopharmaceutical Precursor: For the chelation of radioisotopes (e.g., 111In, 99mTc, 177Lu) to antibodies and peptides for SPECT/CT imaging and targeted radiotherapy.
• MRI Contrast Agent Conjugation: Site-specific attachment of gadolinium (Gd3+) chelates to targeting vectors to create targeted magnetic resonance imaging (MRI) contrast agents.
• Protein and Antibody Labeling: Stable, covalent conjugation via thiol-maleimide chemistry for creating fluorescent, radioactive, or therapeutic protein conjugates.
• Biomolecule Immobilization: Functionalization of surfaces, nanoparticles, or resins for biosensor development and affinity chromatography.
• Pretargeting Strategies: A key component in multi-step pretargeting systems used in oncology for improved tumor-to-background ratios.
• Research Tool: Used in chemical biology and proteomics for studying protein interactions, trafficking, and function via metal-based tags.

Basic Information

Product Name	Maleimido-Mono-Amide-Dtpa
CAS No.	2032239-75-9
Molecular Formula	C20H28N5O11
Molecular Weight	538.47 g/mol
Synonyms	Maleimido-mono-amide-DTPA; DTPA-monoamide-maleimide; Maleimide-DTPA; p-SCN-Bn-DTPA-maleimide derivative; N-(5-Maleimidopentyl)diethylenetriamine-N,N',N'',N'''-pentaacetic acid; Bifunctional DTPA chelator; Heterobifunctional DTPA crosslinker; DTPA-based maleimide chelator
EINECS	Contact for details

Quality Control

Our Maleimido-Mono-Amide-Dtpa is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.