Description

Sulfo Dbco-Amine CAS NO 2028284-70-8 is a water-soluble, bifunctional linker molecule featuring a strained alkyne (DBCO) and a primary amine group, separated by a sulfonated spacer. This compound is critical for enabling efficient, copper-free click chemistry bioconjugation in aqueous environments, which is essential for maintaining biomolecule integrity. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and advanced material science for labeling proteins, antibodies, and nanoparticles.

Application

• Bioconjugation & Protein Labeling: Site-specific modification of antibodies, proteins, and peptides for diagnostic and therapeutic applications.
• ADC (Antibody-Drug Conjugate) Development: Facilitating the stable and efficient linkage of cytotoxic payloads to targeting antibodies via its amine and DBCO groups.
• Proteomics & Biomarker Discovery: Functionalization of surfaces and beads for pull-down assays and mass spectrometry sample preparation.
• Nanoparticle Functionalization: Coating and targeting ligand attachment to liposomes, dendrimers, and other nanocarriers for drug delivery.
• Hydrogel & Biomaterial Synthesis: Cross-linking agent for creating functionalized, biocompatible polymer networks for 3D cell culture and tissue engineering.
• Diagnostic Assay Development: Conjugation of detection probes (e.g., fluorophores, enzymes) to capture molecules in ELISA and lateral flow assays.
• Chemical Biology Tool Development: Synthesis of activity-based probes and affinity tags for studying enzyme function and protein interactions.

Basic Information

Product Name	Sulfo Dbco-Amine
CAS No.	2028284-70-8
Molecular Formula	C₂₀H₂₀N₂O₆S₂
Molecular Weight	456.51 g/mol
Synonyms	DBCO-Sulfo-Amine; Sulfo-DBCO-Amine; 3-((6-((2,5-Dioxopyrrolidin-1-yl)oxy)-6-oxohexyl)amino)-N-(2-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethoxy)-2-oxoethyl)-4-sulfobenzamide; 1-Sulfo-2,5-dioxopyrrolidin-3-yl 6-((2-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethoxy)-2-oxoethyl)amino)hexanoate; Sulfonated DBCO Amine; Water-soluble DBCO amine linker; Dibenzocyclooctyne-sulfo-amine
EINECS	Contact for details

Quality Control

Our Sulfo Dbco-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional group analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and performance data is provided with every shipment to ensure traceability and compliance with research and cGMP-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Functional Group Assay (Amine)	≥ 90%
Solubility (Water)	Clear, colorless solution at 10 mg/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.